Mayo Clinic
This clinical trial studies how well advanced imaging-guided standard dose versus (vs.) dose-intensified radiation therapy (RT) and dose-intensified accelerated RT works in treating patients with newly diagnosed glioblastoma. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. During dose-intensified RT, a higher dose than normal of radiation therapy is delivered over 6 weeks. During dose-intensified accelerated RT, the higher dose of radiation therapy is delivered over a shorter amount of time (2 weeks) than normal (6 weeks). Patients also undergo an advanced brain imaging positron emission tomography (PET)/computed tomography (CT) scan (using a radioactive drug called either FET or FDOPA) prior to RT to that may help doctors better plan the treatment. Dose-intensified and dose-intensified accelerated radiation therapy may be effective in treating patients with newly diagnosed glioblastoma. Giving dose-intensified RT or dose-intensified accelerated RT guided by advanced imaging may work better than standard dose RT in treating patients with newly diagnosed glioblastoma. IND Numbers: 61300, 140882, 176402, 154793, 167879
Inclusion Criteria: * Age ≥ 18 years * Histological confirmation of glioblastoma (IDH-wildtype) * Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 3 at baseline * Provide written informed consent or have a Legally Authorized Representative (LAR) who is responsible for the care and well-being of the potential study participant, provide consent in accordance with ethical, regulatory, and institutional requirements * Willing to return to enrolling institution for follow-up either in-person or by video visit (where indicated) Exclusion Criteria: * Known to be pregnant or nurs…
Undergo blood sample collection
Undergo FET or FDOPA PET/CT
Given via injection
Given IV
Undergo MRI
Undergo dose-intensified photon radiation therapy
Undergo standard photon radiation therapy
Undergo dose-intensified accelerated photon radiation therapy
Undergo accelerated photon radiation therapy
Undergo FET or FDOPA PET/CT
Undergo dose-intensified proton radiation therapy
Undergo standard proton radiation therapy
Undergo dose-intensified accelerated proton radiation therapy
Undergo accelerated proton radiation therapy
Ancillary studies
Given SOC temozolomide