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Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma ( MAC)

Background: \- Uveal coloboma is a condition where the eye does not form normally. It occurs early in the fetus s development during pregnancy. It can lead to…

ColobomaAnophthalmiaMicrophthalmia

Estimated

~$10 – $675

National Eye Institute (NEI)NCT01778543

SPARC - Screening for Lung Cancer With Platelets Via an AI-enabled RNA-based Classifier

The purpose of this study is to test whether combining a unique analytical approach with changes in platelet RNA expression accurately diagnoses lung cancer. U…

Lung CancerLung Nodule

Estimated

~$10 – $750

University of UtahNCT07460440

Phase 1

A Phase I First-in-human Clinical Trial to Evaluate the Safety, Pharmacokinetics, and Antiviral Activity of the Broadly Neutralizing Antibody BNT351 in Adults Living Without and With HIV

This study will test the safety and blood levels of the antibody BNT351 in people living without and with human immunodeficiency virus (HIV). This study will a…

HIV -1 Infection

Estimated

~$10 – $7,500

BioNTech SENCT07392372

Regulation of the Proliferation and Survival of Normal and Neoplastic Human Mast Cells

This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the bod…

MastocytosisMonoclonalBone Marrow+1 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT00044122

Phase 2

The Neurobiology of Suicide

Background: There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sle…

Healthy VolunteersDepression

Estimated

~$10 – $5,625

National Institute of Mental Health (NIMH)NCT02543983

Phase 1

A Phase 1/2, First-in-human, Double-blind, Placebo-controlled Study to Assess Dose, Safety, and Efficacy of UX016 (Sialic Acid-C16 Prodrug) in Adults With GNE Myopathy

The goal of this study is to assess the safety and dose of UX016 and its impact on muscle strength in adults with GNE Myopathy (GNEM).

GNE Myopathy

Estimated

~$10 – $8,750

Ultragenyx Pharmaceutical IncNCT07511556

Observational

Plasma Lipids-dependent Vitamin E Metabolism During Dynamic Hyperlipidemia

Background: Obesity is known to lead to diseases such as diabetes and high cholesterol (or fats) in the blood (hyperlipidemia). But no one knows why. Research…

Lipid Metabolism Disorders

Estimated

~$10 – $5,625

National Heart, Lung, and Blood Institute (NHLBI)NCT07715890

Phase 1

A Phase Ib Dose Escalation/Dose Expansion Study of PTM-101 as an Adjunct to Neoadjuvant Therapy for Treatment Naïve, Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC)

This is a multi-center, non-randomized, single-arm, open-label, phase Ib, dose escalation/dose expansion study of PTM-101 when combined with neoadjuvant chemot…

Pancreatic Ductal AdenocarcinomaBorderline Resectable Pancreatic AdenocarcinomaLocally Advanced Pancreatic Adenocarcinoma+1 more

Estimated

~$10 – $8,750

PanTher TherapeuticsNCT06673017

Phase 2

A Phase 2, Open-label Trial Evaluating the Safety, Tolerability and Efficacy of ION775 in Adults With Hypertriglyceridemia

The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and se…

HypertriglyceridemiaSevere Hypertriglyceridemia

Estimated

~$10 – $8,750

Ionis Pharmaceuticals, Inc.NCT07604974

UCSF Center for Genome Surgery Biobank and Registry

Gene editing approaches (including but not limited to: CRISPR, LNP, AAV, RNAi etc.) for the medical specialty of interventional genomics require (1) determinat…

Any Conditions That Are Genetic or Suspected to be Genetic in Origin

Estimated

~$10 – $675

University of California, San FranciscoNCT07396285

Phase 1

A Phase 1/1b Open-label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN-2787 in Participants With BRAF and/or NRAS Mutation-positive Solid Tumors.

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-2787 in adults with BRAF/NRAS-mutated…

Solid Tumor, AdultNon-small Cell Lung CancerMelanoma

Estimated

~$10 – $7,500

Pierre Fabre MedicamentNCT04913285

Observational

Bone Marrow Aspirate Injections in Knee Arthroscopy: A Randomized, Single-Blind, Controlled Trial

This study will examine whether using bone marrow aspirate (BMA) during knee arthroscopy surgery can improve patient outcomes. The investigators will enroll 50…

Chondral Lesion of the KneeMeniscal InjuriesCartilage Defects of the Knee+1 more

Estimated

~$10 – $6,250

Hospital for Special Surgery, New YorkNCT06893302