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26,899 recruiting studies available now

Group-based Virtual Psychotherapy Intervention for Anxiety and Depression in Patients With Inflammatory Bowel Disease

This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on s…

Crohn's Disease (CD)Ulcerative Colitis (UC)Inflammatory Bowel Diseases (IBD)+2 more

Estimated

~$10 – $6,250

University of ChicagoNCT07796568

Oral Microbial and Immunological Characterization of Patients With Immune Dysfunction

Background: \- Gum disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss if it is…

ImmunosuppressionPeriodontal DiseaseHealthy Subjects+1 more

Estimated

~$10 – $675

National Institute of Dental and Craniofacial Research (NIDCR)NCT01568697

Phase 2

A Phase 2, Open-Label Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SIR2501 and Its Potential to Address Paclitaxel-Induced Peripheral Neuropathy

This Phase 2, open-label study will evaluate the safety, tolerability, and pharmacokinetics of SIR2501 in adults with solid tumors who are scheduled to receive…

Chemotherapy-induced Peripheral Neuropathy

Estimated

~$10 – $8,750

Sironax USA, Inc.NCT07765446

VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Background: \- The Vaccine Research Center (VRC) is dedicated to understanding immune responses associated with prevention and treatment of infectious disease…

Immunity, MucosalImmune System ProcessesBlood Specimen Collection

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT01132859

Phase 2

An Open-Label, Phase 2b, Global Multicenter Cohort Trial to Assess the Safety and Efficacy of Zipalertinib in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Exon 20 Insertion and Uncommon/Single or Compound Epidermal Growth Factor Receptor Mutations.

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non…

Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

Estimated

~$10 – $8,750

Taiho Oncology, Inc.NCT05967689

Phase 2

Phase 2 Study of Futibatinib 20 mg and 16 mg in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusions or Rearrangements

This is an open-label, multinational, randomized Phase 2 study confirming the clinical benefit of 20 mg futibatinib and evaluating the safety and efficacy of 1…

Advanced CholangiocarcinomaFGFR2 FusionsGene Rearrangement

Estimated

~$10 – $8,750

Taiho Oncology, Inc.NCT05727176

PROSPECT: A Registry and Longitudinal Natural History Study of Individuals at Risk for Genetic Prion Disease

PROSPECT is a prospective observational registry and longitudinal natural history study of adults at risk for genetic prion disease.

Prion Diseases

Estimated

~$10 – $1,125

Brian ApplebyNCT07732608

Phase 3

Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if …

Coronary Artery Disease Risk Factors MultipleCoronary Artery Disease ProgressionPrevention & Control+1 more

Estimated

~$10 – $6,250

Duke UniversityNCT07232069

Observational

Weight Management and Black American Women: Targeting Social Networks as a Strategy to Improve Outcomes (BRIDGE & Friends)

Aim 1. Conduct a 6-month (24-session) RCT comparing MedDiet-WL to MedDiet-SN among 268 older adults with obesity (50-79 years, BMI = 30-50 kg/m²). We hypothesi…

Obesity & Overweight

Estimated

~$10 – $6,250

University of Illinois at ChicagoNCT07798557

Phase 3

A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to semaglutide SC once wee…

A First-in-Human Phase 1b, Single-Blind, Placebo-controlled Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study to Evaluate Safety and Pharmacokinetics of GS-0415 in People With HIV-1 Who Are Virologically Suppressed on Antiretroviral Treatment

The goals of this clinical study are to learn more about the study drug GS-0415, safety, tolerability, and pharmacokinetics (PK) of single ascending doses (SAD…

HIV -1 Infection

Estimated

~$10 – $7,500

Gilead SciencesNCT07719491

Observational

Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families

This R01 is in response to RFA-DK-19-021, Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes. The objective is to test the feasibility …

Type 1 Diabetes

Estimated

~$10 – $6,250

Nemours Children's ClinicNCT05268250