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A Phase 1 Study of JNJ-87890387, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3 (ENPP3) x CD3 Bispecific Antibody, for Advanced Solid Tumors

The purpose of this study is to determine safety and recommended phase 2 dose(s) (RP2Ds) of JNJ-87890387 and to determine the safety of JNJ-87890387 at the RP2…

NeoplasmsAdvanced Solid Tumors

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT06178614

RRA-18896: An Observational Study to Assess the Long-term Safety of Ustekinumab Versus Other Biologic Therapies Among Patients With Crohn's Disease: A New-User Cohort Study Using the Department of Defense Electronic Health Records Database

The purpose of this study is to estimate and compare the incidence of overall malignancy, serious infection, and opportunistic infections between new users of …

Crohn DiseaseColitis, Ulcerative

Estimated

~$10 – $1,050

Janssen Scientific Affairs, LLCNCT04372108

Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Background: \- Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year. Researchers want to gath…

Non-Small Cell Lung CancerSmall Cell Lung CancerExtrapulmonary Small Cell Cancer+2 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT02146170

PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders

The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM)…

Type III AchalasiaEGJ Outflow Obstruction With Spastic/Hypercontractile FeaturesJackhammer Esophagus+1 more

Estimated

~$10 – $750

Northwestern UniversityNCT07293689

Phase 2

Odronextamab for Relapsed/Refractory Large B-Cell Lymphomas Before Definitive Lymphoma-Directed Therapies

This phase II trial tests the effectiveness of odronextamab given before chimeric antigen receptor T (CAR-T) cell therapy (bridging therapy) in patients with l…

Recurrent Diffuse Large B-Cell LymphomaRecurrent Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent Grade 3b Follicular Lymphoma+9 more

Estimated

~$10 – $6,250

Observational

Supporting Health and Empowerment Through Contingency Management and Affect Regulation (SHE CARES)

The goal of the SHE CARES study is to better understand factors that influence engagement in HIV prevention and substance use services among women who use stim…

HIV Risk

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT07792161

Observational

Pilot Trial of a Risk-informed Shared-decision Engagement Strategy

The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes. …

PrediabetesPrediabetes (Insulin Resistance, Impaired Glucose Tolerance)

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT07553325

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Diseases

Selected individuals suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI. Blood samples may b…

Malignant NeoplasmsHereditary Neoplastic SyndromesKidney Cancer+2 more

Estimated

~$10 – $675

National Cancer Institute (NCI)NCT00026884

Quantifying Associations of Stress and Inflammation-Associated Oral Biomarkers With Oral Health, Oral Health Behaviors, Systemic Biomarkers and Clinical Phenotype in Individuals With Alcohol Use Disorder (AUD)

Background: People with alcohol use disorder (AUD) have a higher rate of dental and gum disease. Poor oral health can increase the risk of other diseases, suc…

Alcohol Use DisorderAlcohol Dependence

Estimated

~$10 – $675

National Institutes of Health Clinical Center (CC)NCT06684483

Phase 1

Phase I Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-Small Cell Lung Cancer

Background: Non-small cell lung cancer (NSCLC) can be hard to treat and is often fatal. People with NSCLC commonly have changes in the bacteria that populate …

Advanced Non Small Cell Lung Cancer

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05777603

Phase 1

A Phase 1/2, Open-Label, Multicenter, Dose Finding and Dose Expansion Study to Investigate the Safety, Tolerability, and Efficacy of ALXN2350 Gene Therapy in Adult Participants With BAG3 Mutation Associated Dilated Cardiomyopathy

This Phase 1/2 study is an open-label, dose finding and dose expansion study investigating the safety, tolerability, and efficacy of a single IV infusion of AL…

BAG3 Mutation Associated Dilated Cardiomyopathy

Estimated

~$10 – $8,750

Alexion Pharmaceuticals, Inc.NCT07218887

Phase 1

A Phase 1b Study of Pasritamig (JNJ-78278343), a T-cell Redirecting Agent Targeting Human Kallikrein 2 (KLK2), in Combination With JNJ-86974680, an A2a Receptor (A2aR) Antagonist, for Prostate Cancer

The purpose of this study is to identify the recommended phase 2 combination dose (RP2CD) of Pasritamig in combination with JNJ-86974680 in Part 1 (Dose findin…

Prostatic Neoplasms

Estimated

~$10 – $8,750

Janssen Research & Development, LLCNCT07319871