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27,031 recruiting studies available now

A Multi-center, Open-label Study to Determine the Dose and Safety of Oral Asciminib in Pediatric Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia in Chronic Phase (Ph+ CML-CP), Previously Treated With One or More Tyrosine Kinase Inhibitors

The aim of this study is to support development of asciminib in the pediatric population (1 to \<18 years) previously treated with one or more TKIs. Full extra…

Myeloid Leukemia, Philadelphia Positive

Estimated

~$10 – $8,750

Novartis PharmaceuticalsNCT04925479

Observational

EMBRACE - Empowering Monterey Bay Residents for Activated, Collaborative, and Equitable Care

The purpose of the EMBRACE Study is to evaluate whether a facilitated intervention improves shared decision-making (SDM) and patient activation among low-incom…

Shared Decision-MakingQuality of LifeAdvanced Illness+1 more

Estimated

~$10 – $6,250

Stanford UniversityNCT07652359

Genomic and Proteomic Analysis of Disease Progression in Idiopathic Pulmonary Fibrosis

The purpose of the study is to identify genetic and biologic markers that may predict the loss of lung function due to idiopathic pulmonary fibrosis. The studi…

Idiopathic Pulmonary Fibrosis

Estimated

~$10 – $750

University of PittsburghNCT00373841

Phase 1

First-in-Human Phase I Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Background: Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or re…

Advanced Solid TumorsMetastatic Pancreatic CancerPediatric Solid Tumor+3 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT04222413

Phase 2

KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury

A study looking at the safety and tolerability of KAP (Ketamine-Assisted Psychotherapy) in the burn population.

PTSD and Trauma-related Symptoms

Estimated

~$10 – $7,500

Irma FlemingNCT07563296

Phase 1

A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303/BNT323 in Patients With Advanced/Metastatic Solid Tumors

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors …

HER2-positive Advanced Solid Tumor

Estimated

~$10 – $8,750

DualityBio Inc.NCT05150691

Phase 2

A Phase II Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Advanced Melanoma Receiving Post-progression Dual Immune Checkpoint Inhibitor Therapy

The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and eff…

Metastatic MelanomaSkin Cancer

Estimated

~$10 – $6,250

Massachusetts General HospitalNCT05779423

Phase 2

A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis …

Ulcerative Colitis

Estimated

~$10 – $8,750

Genentech, Inc.NCT06979336

Phase 4

A Double-Blind Prospective RCT Assessment of ESP Blocks for Analgesia Following Posterior Spinal Fusion

This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervica…

Postoperative Pain

Estimated

~$10 – $6,250

Duke UniversityNCT07228039

Phase 3

A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm Study to Investigate the Efficacy and Safety of Adjunctive Treatment With Brenipatide in Delaying Time to Relapse Compared With Placebo in Adult Participants With Major Depressive Disorder (RENEW-MDD- 2)

This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return o…

Depressive Disorder, Major

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07775300

Phase 1

First-in-human, Open-label, Multi-site, Phase I/IIa, Dose Escalation Trial With Expansion Cohorts to Evaluate Safety and Preliminary Efficacy of BNT329 in Participants With Advanced Solid Tumors Known to Express CA19-9

The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of side effe…

Advanced Solid Cancers

Estimated

~$10 – $7,500

BioNTech SENCT07186842

Phase 3

An Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of ALXN2220 in Adult Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

The purpose of Study ALXN2220-ATTRCM-302 is to evaluate the long-term safety, tolerability and efficacy of ALXN2220 in adult participants with ATTR-CM treated …

Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Estimated

~$10 – $8,750

Alexion Pharmaceuticals, Inc.NCT07789483