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First-in-Human Phase I Trial to Investigate the Safety, Tolerability, Pharmacokinetics, Biological and Clinical Activity of Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

Background: Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or re…

Advanced Solid TumorsMetastatic Pancreatic CancerPediatric Solid Tumor+3 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT04222413

Phase 2

KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury

A study looking at the safety and tolerability of KAP (Ketamine-Assisted Psychotherapy) in the burn population.

PTSD and Trauma-related Symptoms

Estimated

~$10 – $7,500

Irma FlemingNCT07563296

Phase 1

A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303/BNT323 in Patients With Advanced/Metastatic Solid Tumors

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors …

HER2-positive Advanced Solid Tumor

Estimated

~$10 – $8,750

DualityBio Inc.NCT05150691

Phase 2

A Phase II Study of Core Needle Biopsy and Cryoablation of an Enlarging Tumor in Patients With Advanced Melanoma Receiving Post-progression Dual Immune Checkpoint Inhibitor Therapy

The aim of this study is to find out whether the combination of two approved drugs, ipilimumab and nivolumab, in combination with cryoablation are safe and eff…

Metastatic MelanomaSkin Cancer

Estimated

~$10 – $6,250

Massachusetts General HospitalNCT05779423

Phase 2

A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis …

Ulcerative Colitis

Estimated

~$10 – $8,750

Genentech, Inc.NCT06979336

Phase 4

A Double-Blind Prospective RCT Assessment of ESP Blocks for Analgesia Following Posterior Spinal Fusion

This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervica…

Postoperative Pain

Estimated

~$10 – $6,250

Duke UniversityNCT07228039

Phase 3

A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Arm Study to Investigate the Efficacy and Safety of Adjunctive Treatment With Brenipatide in Delaying Time to Relapse Compared With Placebo in Adult Participants With Major Depressive Disorder (RENEW-MDD- 2)

This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return o…

Depressive Disorder, Major

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07775300

Phase 1

First-in-human, Open-label, Multi-site, Phase I/IIa, Dose Escalation Trial With Expansion Cohorts to Evaluate Safety and Preliminary Efficacy of BNT329 in Participants With Advanced Solid Tumors Known to Express CA19-9

The main goal of this study is to evaluate the safety of BNT329 and to identify the best dose of BNT329. This will be done by measuring the number of side effe…

Advanced Solid Cancers

Estimated

~$10 – $7,500

BioNTech SENCT07186842

Phase 3

An Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of ALXN2220 in Adult Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

The purpose of Study ALXN2220-ATTRCM-302 is to evaluate the long-term safety, tolerability and efficacy of ALXN2220 in adult participants with ATTR-CM treated …

Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Estimated

~$10 – $8,750

Alexion Pharmaceuticals, Inc.NCT07789483

Prospective Collection And Molecular Analysis Of Biospecimens And Clinical Data From Patients With Urothelial Carcinoma And Related Malignancies Of The Urinary Tract

To collect, process, store, and study biological samples and related clinical and imaging data from participants with known or suspected urothelial carcinoma o…

Prospective CollectionMolecular AnalysisBiospecimens+2 more

Estimated

~$10 – $750

M.D. Anderson Cancer CenterNCT07789119

Observational

Digital Technology to Enhance Access to and Effectiveness of Cancer Genetic Counseling: Effective Familial OutReach Via Tele-genetics (EfFORT) Trial & Supporting Test Result Interpretation and Variant Education (STRIVE) Trial

The purpose of this study is to examine the impact of new cancer genetic counseling models that aim to increase patient engagement with the genetics team. To d…

BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT05420064

An International Observational Study of Adults With Acute Infection

Prospective, longitudinal studies of people with acute infections are essential to understand risk factors, clinical manifestations, pathobiology, and manageme…

Infectious Disease

Estimated

~$10 – $750

University of MinnesotaNCT07069400