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A Phase 1, Open Label, Multiple-Dose Study to Assess the Changes in Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Following Treatment With LY3439539 in Participants With Symptomatic Alzheimer's Disease

The purpose of this study is to see how LY3439539 affects certain proteins found in the spinal fluid of participants with Alzheimer's disease. Participation i…

Alzheimer Disease

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07598370

Phase 2

Phase II Evaluation of Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

This is a Phase II study to determine the rate of stabilization or disease improvement from investigational decitabine/cedazuridine (INQOVI) treatment in subje…

MesotheliomaMalignant Mesothelioma (MM)Early-stage Mesothelioma+3 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05960773

Deep Brain Stimulation (DBS) Retrospective Outcomes Study

The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified…

Parkinson DiseaseEssential TremorDystonia

Estimated

~$10 – $1,050

Boston Scientific CorporationNCT03664609

Phase 4

Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location …

Parkinson Disease

Estimated

~$10 – $6,250

Emory UniversityNCT06234995

Phase 2

Phase II Haploidentical Hematopoietic Stem Cell Transplantation for Participants With Germline RUNX1 Associated Hematologic Malignancies

Background: Some blood cancers can be caused by germline variants (changes) in a person s RUNX1 gene. Germline variants are genetic inherited changes a person…

Core Binding Factor Alpha SubunitsHematologic NeoplasmsLeukemia+1 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT07524530

Phase 3

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

The purpose of this study is to evaluate the ability of dapirolizumab pegol (DZP) as an add-on treatment to standard of care (SOC) medication to achieve clinic…

Systemic Lupus Erythematosus

Estimated

~$10 – $8,750

UCB Biopharma SRLNCT06617325

Phase 1

Phase I/II Trial of Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

Background: Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are blood disorders that can cause serious complications …

Myelodysplastic Syndromes

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT06303193

Observational

Prophylaxis With Direct-acting Antivirals for Kidney Transplantation From Hepatitis C Virus-Infected Donors to Uninfected Recipients: a Randomized Controlled Trial

This study is being done to find out the best time to start medication for Hepatitis C Virus (HCV) in HCV-negative recipients of HCV-positive (HCV D+/R-) kidne…

HCV

Estimated

~$10 – $6,250

Johns Hopkins UniversityNCT05653232

A Pilot Study of the Womb Watch App: Fetal Assessment Using the Microphone of the Smartphone

The surveillance of pregnancies at risk for fetal loss secondary to high-risk maternal or fetal conditions remains a mainstay of perinatal care. Current testin…

Assessment of Fetal MovementPregnancyPregnancy Complications+4 more

Estimated

~$10 – $1,125

Kenneth Moise MDNCT07626112

Phase 2

Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers

Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in …

Healthy Volunteers

Estimated

~$10 – $7,500

National Center for Complementary and Integrative Health (NCCIH)NCT07504601

Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age

A child is eligible to participate in this study because she is having surgery on her ovary. The investigators may obtain a sample of any discarded tissue from…

Benign Cysts OvarianCystectomyTorsion+1 more

Estimated

~$10 – $750

Ann & Robert H Lurie Children's Hospital of ChicagoNCT04118712

Phase 1

A Phase 1/2, Open-Label, Multi-Center, Dose Escalation, Dose Expansion, and Single Repeat Dose Study of TSRA-196 in Adults With the PiZZ Genotype Who Have Lung and/or Liver Disease Associated With Severe Alpha-1 Antitrypsin Deficiency

This is a Phase 1/2, open-label, multi-center, dose escalation (Part 1), dose expansion (Part 2), and single repeat dose (Part 3) study to evaluate the safety,…

Alpha-1 Antitrypsin Deficiency (AATD)

Estimated

~$10 – $8,750

Tessera Therapeutics, Inc.NCT07227207