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27,157 recruiting studies available now

A Phase 1, Open-Label Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B455 in Patients With Selected Advanced or Metastatic Solid Tumors

The goal of this clinical trial is to learn if BGB-B455 can treat advanced or metastatic solid tumors expressing claudin 6 (CLDN6), a protein that is found on …

Advanced Solid TumorMetastatic Solid Tumor

Estimated

~$10 – $7,500

BeOne MedicinesNCT06803680

Phase 2

A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects With Refractory Focal Onset Epilepsy

The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.

Focal Epilepsy

Estimated

~$10 – $8,750

Biohaven Therapeutics Ltd.NCT06132893

Use of Viscoelastic Assays Beyond Coagulation: Pre- and Post-operative TEG

The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and…

Liver CancerEsophageal CancerColorectal Cancer+4 more

Estimated

~$10 – $750

University of Colorado, DenverNCT05517811

Phase 3

A Phase 3, Double-Blind, Randomized Trial Evaluating the Efficacy and Safety of Elritercept (TAK-226) Compared to Placebo in Participants With Myelofibrosis and Anemia on Concurrent Ruxolitinib Therapy

The main aim of this study is to find out how well elritercept works to improve anemia in participants with myelofibrosis (MF) who are taking ruxolitinib when …

A Phase I, Multicentre, Single-Dose, Non-Randomised, Open-Label, Parallel-Group Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of AZD4144

This Phase I, open-label, parallel group study will investigate the single oral dose PK, safety, and tolerability of AZD4144 to male and female participants wi…

Hepatic Impairment

Estimated

~$10 – $7,500

AstraZenecaNCT07783308

Phase 1

A Phase 1 Study of the Safety and Tolerability of DUVAX, a Dual-Target Alzheimer's Vaccine (Amyloid-Beta and Tau), in Healthy Volunteers

This Phase 1 study will test the safety and immune response of the investigational vaccine DUVAX in healthy adults. Participants will be randomly assigned to r…

Alzheimer DiseaseAlzheimer Disease (AD)Preclinical Alzheimer's Disease

Estimated

~$10 – $8,750

Nuravax, Inc.NCT07142278

Phase 3

Efficacy, Safety, and Pharmacokinetics of Orforglipron Once Daily Oral Versus Placebo in Adolescent Participants Who Have Obesity, or Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind Trial (ADVANCE-ATTAIN-ADOLESCENTS)

The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of orforgl…

ObesityOverweight

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT06672939

ObservationalRemote eligible

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Phase III Randomized Controlled Trial

Background: RASopathies are a group of genetic diseases that affect a child s development. They cause physical, cognitive, and behavioral symptoms. Caring for…

Neurofibromatosis 1Noonan SyndromeLegius Syndrome+2 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05361811

Phase 1

A Phase I/II Pilot Study of Memory-like NK Cells to Consolidate TCRαβ T Cell Depleted Haploidentical Transplant in High-risk AML

This trial represents a single institution phase I/II pilot study with the primary objective of establishing the safety and feasibility of generating and infus…

AML, ChildhoodAmlAcute Myeloid Leukemia, Pediatric+1 more

Estimated

~$10 – $6,250

Washington University School of MedicineNCT06158828

Observational

ONE SHOT: Single-Fraction Adaptive MR-Guided Radiation Therapy for Metastatic Solid Tumors

This clinical trial studies the side effects of magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) and to see how well it works in treat…

Metastatic Malignant Solid Neoplasm

Estimated

~$10 – $6,250

Jonsson Comprehensive Cancer CenterNCT07671768

Observational

Continuous Versus Intermittent Ward Monitoring on Vital Sign Abnormalities, Clinical Interventions, and Serious Complications: the CONSTANT Trial

The investigators will randomize adults having major non-cardiac inpatient surgery to blinded versus unblinded continuous postoperative vital sign monitoring (…

Surgery

Estimated

~$10 – $6,250

The University of Texas Health Science Center, HoustonNCT06232876

Phase 2

A Phase II, Randomized, Placebo-Controlled, Double-Blind, Adaptive Study to Assess the Safety and Efficacy of Intravenous J147 Combined With Endovascular Therapy in Patients With Acute Ischemic Stroke

The goal of this clinical trial is to find out if the drug J147 improves outcomes for persons who have had an ischemic stroke. It also will learn about the saf…

Acute Ischemic Stroke

Estimated

~$10 – $8,750

Abrexa Pharmaceuticals, Inc.NCT07430917