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Safety, Efficacy, and Mechanism of Pre-operative Spatially Fractionated GRID Radiation Therapy in Patients With Extremity Soft Tissue Sarcoma: A Pilot Study

Patients with extremity soft tissue sarcoma (STS) are at high risk of recurrence. Pre-operative radiotherapy is used to increase the safe removal of tumors and…

Sarcoma

Estimated

~$10 – $6,250

UNC Lineberger Comprehensive Cancer CenterNCT06073067

Observational

Observational Approach Versus Surgical Intervention for Stones

The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to u…

NephrolithiasisKidney Stone

Estimated

~$10 – $6,250

Children's Hospital of PhiladelphiaNCT07718802

Phase 1

A Single and Repeat Dosing and Expansion Study of the Safety, Drug Exposure and Clinical Activity of R-5780 in Combination With a PD-1 (Checkpoint Protein on Immune Cells Called T Cells) Pathway Checkpoint Inhibitor in Patients With Solid Tumors

The goal of this study is determine the safety and tolerability of orally taken probiotic (R-5780) in patients currently on a PD-1 Pathway Checkpoint Inhibitor…

Solid Tumor, AdultSolid TumorMelanoma+3 more

Estimated

~$10 – $8,750

Rise Therapeutics LLCNCT06398418

Phase 2

A Phase 2, Open-label Study of VS-7375, an Oral KRAS G12D (ON/OFF) Inhibitor, in Patients With Previously Treated, Advanced KRAS G12D-Mutated Non-Small Cell Lung Cancer (TARGET-D 202)

This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Non-Small Cel…

Non-Small Cell Lung Cancer

Estimated

~$10 – $8,750

Verastem, Inc.NCT07659782

Phase 1

Protocol for Maintaining and Improving Mental Status in Alzheimer's Disease (PROMIS-AD): a Pilot Study of Large-Coil Parietal Repetitive Transcranial Magnetic Stimulation for Alzheimer&Amp;Amp;#39;s Disease

The goal of this clinical trial is to learn if using large-coil (or "deep") repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus and sur…

Alzheimer&Amp;Amp;#39;s DiseaseAlzheimer DiseaseDementia Alzheimer Type+4 more

Estimated

~$10 – $6,250

University of California, Los AngelesNCT06597942

Phase 3

A Phase III, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of BI 1291583 2.5 mg Administered Once Daily for up to 76 Weeks in Patients With Bronchiectasis (The AIRTIVITY™ Study)

This study is open to adults and adolescents aged 12 to under 18 with bronchiectasis. People can participate in this study if they produce sputum and have had …

Bronchiectasis

Estimated

~$10 – $7,500

Boehringer IngelheimNCT06872892

An Observational Study of Visual Attention, Object Recognition, and Eye Movements in Healthy Volunteers

Background: Vision is vital for many of our daily activities. Researchers want to learn more about how we aim our eyes (that is, what images, such as faces, i…

Healthy Volunteer

Estimated

~$10 – $675

National Eye Institute (NEI)NCT07756853

Phase 4

A Phase IV Open-Label Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Patients With Spinal Muscular Atrophy After Gene Therapy

This is an open-label, single-arm, multicenter clinical study to evaluate the effectiveness and safety of risdiplam administered as an early intervention in pe…

Muscular Atrophy, Spinal

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT05861986

Clinical and Molecular Studies of Li-Fraumeni Syndrome and TP53-associated Disorders

Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome are cancer predisposition syndromes due to germline aberrations in the TP53 gene. Patients with …

Li-Fraumeni SyndromeLi-Fraumeni-Like Syndrome

Estimated

~$10 – $750

Abramson Cancer Center at Penn MedicineNCT04367246

Phase 2

An Open Label, Phase II Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Cancers Hoosier Cancer Research Network BRE17-141

Patient will be treated with neratinib, an aromatase inhibitor and trastuzumab for 24 weeks prior to surgery, following an initial 3 weeks of neratinib alone, …

Breast CancerHER2-positive Breast CancerER Positive Breast Cancer+1 more

Estimated

~$10 – $7,500

Ruth O'ReganNCT04886531

Phase 3

A Randomised, Double-blind, Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults with Mo…

Chronic Obstructive Pulmonary Disease (COPD)

Estimated

~$10 – $7,500

AstraZenecaNCT06878261

Observational

Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

This study will compare two different methods to pace the heart to treat heart failure including: 1. The current standard method of implanting a pacing lead i…

Heart Failure - NYHA II - IV

Estimated

~$10 – $8,750

Boston Scientific CorporationNCT07069738