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A Phase 3, Randomized, Double-Blind Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Participants With Obesity or Overweight With Type 2 Diabetes Mellitus

The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity and…

ObesityOverweightDiabetes Mellitus, Type 2

A Phase 2 Study to Evaluate the Efficacy, Pharmacokinetics, Safety, and Tolerability of VIM0423 in Adults With Parkinson's Disease Tremor Insufficiently Responsive to Dopaminergic Therapy

Vista PD is a randomized, placebo-controlled, multicenter study to evaluate the efficacy, PK, safety, and tolerability of VIM0423 in adults with Parkinson's di…

PARKINSON DISEASE (Disorder)

Estimated

~$10 – $8,750

Vima TherapeuticsNCT07804615

Prospective, Observational Study in Participants With Active Systemic Lupus Erythematosus (SLE) (Including Lupus Nephritis) With Inadequate Response to Glucocorticoids and At Least 2 Immunosuppressants

The purpose of this study is to characterize the efficacy and safety of current standard of care treatment options in participants with active systemic lupus e…

Systemic Lupus Erythematosus (SLE)

Estimated

~$10 – $1,125

Bristol-Myers SquibbNCT07175285

Phase 2

Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee

This clinical trial is being done to better understand how daily treatment with Tetrahydrocannabinol (THC), Cannabidiol (CBD), or the combination of CBD plus T…

Osteoarthritis, KneeOsteoarthritis of the Knee

Estimated

~$10 – $7,500

Steven E Harte, PhDNCT04992624

Observational

Development and Pilot Evaluation of a Novel Mobile Health Intervention for Young Adult Tobacco Cessation

Tobacco use is the leading cause of preventable cancer deaths. Among young adults, approximately 1 in 5 use commercial nicotine and tobacco products, putting t…

Tobacco-Related Carcinoma

Estimated

~$10 – $6,250

Fred Hutchinson Cancer CenterNCT07571018

Phase 4

Vitamin D Homeostasis in Sarcoidosis

This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient pa…

SarcoidosisVitamin D Insufficiency

Estimated

~$10 – $6,250

University of Texas Southwestern Medical CenterNCT03621553

Phase 3

A Phase 3, Multicenter, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Brenipatide Compared With Placebo for the Treatment of Adult Participants With Moderate-to-Severe Alcohol Use Disorder (RENEW-ALC-1)

The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use Disorder (…

Alcohol Use Disorder

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07219966

Observational

Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion

This single-center, prospective, randomized study will evaluate the safety and feasibility of Intracardiac echocardiography (ICE)-guided Left atrial appendage …

Left Atrial Appendage Closure

Estimated

~$10 – $7,500

Baylor Research InstituteNCT06348394

Neurocognitive Outcome as a Metric for Evaluating Therapeutic Intervention and Treatment Mechanisms in Congenital Central Hypoventilation Syndrome (CCHS): A Multi-Site Study Using The NIH Toolbox

Congenital central hypoventilation syndrome (CCHS) is a rare disorder of autonomic and respiratory regulation that frequently alters oxygen delivery to the bra…

Congenital Central Hypoventilation SyndromeCongenital Central HypoventilationCCHS+3 more

Estimated

~$10 – $1,125

Ilya KhaytinNCT03568669

Controls and Healthy Vasculature Initiative

Background: Diseases involving blood, blood vessels, and immune systems are leading causes of death in the United States. Researchers studying these diseases …

Vascular And Immunologic DiseasesHealthy Volunteers

Documented

$50/visit

National Heart, Lung, and Blood Institute (NHLBI)NCT05403151

Phase 2

A Phase 2, Randomized, Masked, Placebo-Controlled Study of Subcutaneously Administered ADX-038 in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Phase 2 study is designed to assess the efficacy of ADX-038 compared with placebo in participants with GA secondary to AMD. Safety, pharmacokinetics (PK), and …

Geographic Atrophy Secondary to Age-related Macular Degeneration

Estimated

~$10 – $8,750

ADARx Pharmaceuticals, Inc.NCT06990269

Phase 4

A Phase IV, Open-Label, Single-Arm Study of Prophylaxis for Datopotamab Deruxtecan-related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer (TROPION-SWISH)

This is a multicenter, open-label, single-arm study of prophylaxis for Dato-DXd-related stomatitis in eligible patients with metastatic or inoperable locally r…

Stomatitis

Estimated

~$10 – $7,500

AstraZenecaNCT07357597