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Phase 1

A Phase I/II Open-label Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD6750, a CD8 Guided IL-2 Agent Alone and in Combination With Other Anti-cancer Agents in Participants With Select Advanced or Metastatic Solid Tumors

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

MelanomaNon-small Cell Lung CancerSquamous Cell Carcinoma (Skin)+6 more

Estimated

~$10 – $7,500

AstraZenecaNCT07115043

Phase 1

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Research…

Polycystic Ovary Syndrome

Estimated

~$10 – $5,625

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT03049462

Phase 2

Optimal Treatment by Invoking Biologic Clusters in Renal Cell Carcinoma (OPTIC RCC)

This phase II trial tests whether using genetic testing of tumor tissue to select the optimal treatment regimen works in treating patients with clear cell rena…

Advanced Clear Cell Renal Cell CarcinomaMetastatic Clear Cell Renal Cell CarcinomaStage III Renal Cell Cancer AJCC v8+1 more

Estimated

~$10 – $6,250

Vanderbilt-Ingram Cancer CenterNCT05361720

Observational

Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome

The purpose of this study is to test if Variable Pulse TMS (Transcranial Magnetic Stimulation) can result in objective improvements in patients with Post COVID…

Post COVID-19 Condition

Estimated

~$10 – $6,250

Mayo ClinicNCT06865222

Smidt Heart Institute Takotsubo Registry

The Cedars-Sinai SHI Takotsubo Registry and Proteomic Study is an observational registry that will collect retrospective and prospective demographic, clinical,…

Takotsubo Cardiomyopathy

Estimated

~$10 – $750

Cedars-Sinai Medical CenterNCT03910569

Phase 1

A Pilot Study of Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies

This single arm pilot phase I study with safety run-in is designed to estimate the safety and efficacy of a familial mismatched or haploidentical hematopoietic…

Pediatric Hematologic Malignancies

Estimated

~$10 – $6,250

Washington University School of MedicineNCT05011422

Observational

Communicating Options for Advanced Breast Cancer Support and Treatment (COAST)

The goal of this pilot study is to understand and improve the shared decision-making process between people with advanced breast cancer and their providers reg…

Breast Cancer MetastaticAdvanced Breast CancerStage 4 Breast Cancer+1 more

Estimated

~$10 – $6,250

Weill Medical College of Cornell UniversityNCT07635147

Phase 1

Phase 1b Study Of Allogeneic CAR TROP2/IL15 Transduced TGFBR2 KO CB NK-Cells (TRICK-NK) In Combination With Trastuzumab Deruxtecan (T-Dxd) In Treatment-Refractory Breast Cancers

The goal of this clinical research study is to find the highest tolerable dose of TGFBR-2 KO CD70 CAR NK (TRICK-NK) in combination with 2 doses of T-Dxd that c…

Breast Cancer

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT07553390

Observational

Improving Maternal and Child Health Through Point-of-care STI Testing (MATCH-POINT)

The goal of this clinical trial is to learn if point-of-care tests (POCTs) for sexually transmitted infections (STIs) improve the timely treatment of syphilis,…

Treponema Pallidum InfectionChlamydia Trachomatis InfectionNeisseria Gonorrheae Infection+2 more

Estimated

~$10 – $6,250

Emory UniversityNCT07290439

Phase 4

A Pilot Study to Assess Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, …

Surgery, Upper Extremity

Estimated

~$10 – $6,250

University of ChicagoNCT07773155

Phase 2

Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer

This is a non-comparative randomized Phase 2 study using the INITIUM regimen with or without elective nodal irradiation (ENI) delivered before surgery for rese…

Head and Neck Cancer Squamous Cell Carcinoma

Estimated

~$10 – $6,250

Medical College of WisconsinNCT07773987

Phase 2

Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury

This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems wh…

Acute Kidney InjuryCirrhosisDecompensated Cirrhosis of Liver

Estimated

~$10 – $7,500

Giuseppe Cullaro, MDNCT06937307