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Randomized Phase II/III Trial of Adjuvant Radiation Therapy With Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in…

Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaStage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7+6 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT01810913

Observational

Evaluating the Impact of Digital Behavioral Interventions to Address Insomnia and Depression in Breast Cancer Survivors Using an Adaptive Design

Co-occurring symptoms of insomnia and depression is very common in breast cancer survivors, and it is critical that scalable and easily accessible digital beha…

InsomniaDepression

Estimated

~$10 – $6,250

University of VirginiaNCT07721064

Patient-centered Precision Medicine Lab Result Communication for Older Adults - Validation and Refinement of an Existing Chronic Kidney Disease (CKD) Risk Model

This study aims to improve how lab results are communicated to older adults by refining a predictive model that uses electronic health record (EHR) data. The m…

Predictive Modeling

Estimated

~$10 – $750

University of California, Los AngelesNCT06995365

Phase 3

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Maintenance of Effect of NBI-1065845 as an Adjunctive Treatment in Subjects With Major Depressive Disorder (MDD)

The primary objective of this study is to evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in delaying relapse of depressi…

Major Depressive Disorder

Estimated

~$10 – $8,750

Neurocrine BiosciencesNCT07196501

Phase 2

Screening Trial for Pain Relief in Schwannomatosis (STARFISH)

This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple…

SchwannomatosisSchwannomasPain, Chronic

Estimated

~$10 – $6,250

Massachusetts General HospitalNCT05684692

Observational

A Short Wave Infrared Otoscope for Objective Middle Ear Effusion Diagnosis

The aim of this study is to provide preliminary data to support future studies to demonstrate that the short wave infrared (SWIR) otoscope is a better diagnost…

Otitis MediaOtitis Media ChronicOtitis Media Effusion

Estimated

~$10 – $6,250

Stanford UniversityNCT06944795

Observational

Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients

This study evaluates the feasibility and preliminary effects of precision tobacco treatment, compared to usual care, on promoting tobacco treatment in oncology…

Smoking CessationSmokingPhysician's Role

Estimated

~$10 – $6,250

Washington University School of MedicineNCT07166120

Supplementation of Pomegranate Dietary Supplements and Characterization of Urolithin Metabotypes in Patients With Alcohol Use Disorder (AUD) and Alcohol-associated Liver Disease (ALD)

The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called urolithins upon consumption of pomegranate…

Alcohol Use DisorderAlcohol-associated Liver DiseaseAlcoholic Cirrhosis+1 more

Estimated

~$10 – $750

University of LouisvilleNCT07678567

Phase 1

Study of NMS-03305293, a Non-Trapping PARP1-Specific PARP Inhibitor in Relapsed Small Cell Lung Cancer

This is an open-label study of NMS-03305293 with Temozolomide (TMZ) in patients with Small Cell Lung Cancer (SCLC). The aim of this study is to determine the s…

Small Cell Lung Cancer

Estimated

~$10 – $7,500

Nerviano Medical SciencesNCT06931626

Phase 2

The Effect of Autologous Serum Tears Diluted to 50% With 0.2% Sodium Hyaluronate-Containing Preservative-Free Artificial Tears Versus Autologous Serum Tears Diluted to 50% With Balanced Salt Solution in Patients With Moderate-to-Severe Dry Eye Disease: A Prospective, Double-Blind, Randomized, Controlled, Contralateral-Eye Study

This study aims to find out whether adding sodium hyaluronate, a moisturizing ingredient commonly found in artificial tears, makes autologous serum eye drops m…

Dry EyeEye DiseasesEyes Dry Chronic

Estimated

~$10 – $6,250

University of MiamiNCT07413172

A Prospective Pilot Study of the Genetic Determinants of Toxicity and Response to Azacitidine and Venetoclax in Patients With Newly Diagnosed Acute Myeloid Leukemia Through Evaluation of Polymorphisms in Pharmacokinetic Genes and Venetoclax Levels

The purpose of this research is to see how certain genetic variations relate to side effects and outcomes experienced while receiving treatment with azacitidin…

Leukemia, Myeloid, Acute

Estimated

~$10 – $750

Wake Forest University Health SciencesNCT06580106

Phase 1

A First-in-Human Phase 1/2, Dose Escalation and Dose Expansion Study to Evaluate Safety, Tolerability, and Preliminary Efficacy of Claudin18.2 (CLDN18.2)-Directed Antibody-Drug Conjugate (ADC) LCB02A in Patients With CLDN18.2-positive Advanced Solid Tumors

This is a Phase 1/2 open label study consisting of dose escalation cohorts (Phase 1) followed by expansion cohorts (Phase 2). The Phase 1 dose escalation popul…

Advanced Solid Tumors

Estimated

~$10 – $8,750

LigaChem Biosciences, Inc.NCT07460375