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A Phase 1/2 Open-label Intrathecal Administration of MELPIDA to Determine Its Safety and Efficacy for Patients With Spastic Paraplegia Type 50 (SPG50) Caused by Mutation in the AP4M1 Gene.

MELPIDA is proposed for the treatment of subjects with SPG50 and targets neuronal cells to deliver a fully functional human AP4M1 cDNA copy via intrathecal inj…

Spasticity, MuscleMicrocephalyIntellectual Deficiency+3 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Elpida Therapeutics SPCNCT05518188

Observational

Assessment of Adolescent and Young Adult Vaccine Confidence and Missed Opportunities for Vaccination in the Mountain West (VACCINE CONFIDENCE - WEST): A Randomized Tailored Vaccine Messaging Intervention

his study will evaluate whether tailored vaccine messaging improves vaccination-related outcomes among parents and caregivers of adolescents. Participants will…

Vaccine ConfidenceAdolescent VaccinationVaccine Uptake

Estimated

~$10 – $750

Actual pay is set by the research site.

University of UtahNCT07878442

Segmental Substrate Isolation for the Treatment of Ventricular Tachycardia in Patients With Structural Heart Disease

The goal of this study is to map conducting channels within scar that cause ventricular tachycardia (VT) in patients with scar in their hearts in order to bloc…

Ventricular Tachycardia (VT)Ischemic CardiomyopathyNonischemic Cardiomyopathy

Estimated

~$10 – $750

Actual pay is set by the research site.

New York Medical CollegeNCT07814079

Phase 1

Phase IB/II Study Combining All-Trans Retinoic Acid (ATRA) With Carfilzomib Based Therapy in Plasma Cell Myeloma Patients Refractory to Carfilzomib

This is a Phase IB/II trial that will investigate the safety, tolerability and efficacy of combination therapy using All-Trans Retinoic Acid (ATRA) with Carfil…

Multiple Myeloma

Estimated

~$150 – $3,000

Actual pay is set by the research site.

The Methodist Hospital Research InstituteNCT06536413

Phase 1

A Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial of Intravitreal 4D-150 Gene Therapy in Adults With Neovascular (Wet) Age-Related Macular Degeneration

Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment. Substudies will eva…

Neovascular (Wet) Age-Related Macular Degeneration

Estimated

~$150 – $4,200

Actual pay is set by the research site.

4D Molecular TherapeuticsNCT05197270

Observational

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

The investigators will study performance on computerized cognitive tasks in healthy participants of different ages to gather normative data for newly developed…

Alzheimer DiseaseCognitive DeclineAging

Estimated

~$10 – $1,050

Actual pay is set by the research site.

Neurobehavioral Systems, Inc.NCT04800588

Phase 2

Systemic and Topical Antiviral Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes - Trials I and II

The goal of this clinical trial is to compare antiviral treatment strategies for cytomegalovirus (CMV) anterior uveitis - a viral infection causing inflammatio…

Cytomegalovirus (CMV)Anterior UveitisInfectious Uveitis+1 more

Estimated

~$75 – $1,800

Actual pay is set by the research site.

University of California, San FranciscoNCT07513623

Multi-Site Feasibility Testing of the Ventricular Assist Device Anticipatory Guidance Tool

There are a variety of educational documents available to help in a participant's decision for VAD implant, however there is little information available to po…

Ventricular Assist DeviceAdvanced Heart FailureAnticipatory Guidance

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Bryan HeartNCT06823583

Observational

Cognitive Rehabilitation to Improve Functioning in Veterans Following COVID-19

Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans' community functioning and qua…

Post-Acute COVID-19 Syndrome

Estimated

~$10 – $675

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT06086379

Observational

A Decentralized, Randomized, Placebo-Controlled Trial Evaluating ProGo® Salmon Protein Hydrolysate Versus Placebo to Improve Body Profile Metrics and Support Overall Wellbeing in Menopausal Women

This study will evaluate whether ProGo®, a salmon protein hydrolysate (SPH), helps to moderate body mass index (BMI) and improve quality of life (QoL) in menop…

Menopause Related Conditions

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Hofseth Biocare ASANCT07611305

Observational

An Innovative Combined Psychosocial Intervention to Improve Productive Community Integration in Homeless-experienced Veterans

The VA has been focused on reducing the number of homeless Veterans nationally. However, it has been very difficult to increase the level of productive activit…

Homeless Persons

Estimated

~$10 – $675

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT07388641

Observational

Sacral Neuromodulation for Male Overactive Bladder

To assess the post-market clinical outcomes of the Axonics SNM System for treatment of overactive bladder in male patients.

Overactive BladderUrinary Urgency IncontinenceBenign Prostatic Hyperplasia+3 more

Estimated

~$10 – $1,050

Actual pay is set by the research site.

Axonics, Inc.NCT06511141