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27,384 recruiting studies available now

A Phase 1/2 Trial of the Safety and Efficacy of SRD-001 (AAV1/SERCA2a) in Subjects With Heart Failure With Reduced Ejection Fraction

It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac c…

Congestive Heart FailureHeart Failure, SystolicHeart Failure+1 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Sardocor Corp.NCT04703842

Phase 1

Neural Response to Inflammatory Challenge in Major Depressive Disorder

This is a parallel group, double-blinded, placebo-controlled study. Participants with MDD (n=90) and HC (n=90) will be randomly assigned (2:1) to receive eithe…

Major Depressive Disorder

Estimated

~$500 – $10,500

Actual pay is set by the research site.

Laureate Institute for Brain Research, Inc.NCT04751331

5-Years Multicentric Prospective Post-Market Clinical Follow-up (PMCF) Comparative Study of CeraRoot Ceramic Dental Implants One-piece Versus Two-piece.

The goal of this cohort observational study is to compare in the survival rate of ceramic dental implants placed in patients with missing or hopeless teeth . T…

EdentulismTooth Loss

Estimated

~$10 – $1,125

Actual pay is set by the research site.

CeraRoot SLNCT06287346

Observational

A Pilot Study Assessing Outcomes Of Artificial Intelligence-Guided Left Bundle Branch Area Pacing For Cardiac Resynchronization In Heart Failure

The purpose of this study is to compare the effectiveness of AI-guided LBBAP versus conventional LBBAP (not AI-guided) in improving CRT response rates and clin…

Heart Failure

Estimated

~$10 – $750

Actual pay is set by the research site.

Mayo ClinicNCT07206602

Feasibility Study of an Intensive Nutrition Therapy Program for Improvement of Obesity and Diabetes in a Low-income Population

This study is being done to better understand whether meal replacements can be an effective tool for weight loss and treatment of elevated blood sugars in peop…

OverweightPreDiabetesDiabetes Type 2+1 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Massachusetts General HospitalNCT05799222

Phase 2

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes to Increase Airway L-arginine/ADMA Ratio and Improve Asthma Control

Patients with obese late onset (after childhood) asthma can have lower FeNO levels, yet be highly symptomatic and poorly responsive to inhaled steroids. This i…

AsthmaObesity

Estimated

~$75 – $2,000

Actual pay is set by the research site.

University of Colorado, DenverNCT03885245

Observational

Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity

The purpose of this study is to evaluate endoscopic sleeve gastroplasty (ESG) for the treatment of obesity. The ESG procedure is an U.S. Food and Drug Administ…

Endoscopic Sleeve GastroplastyObesity

Estimated

~$10 – $750

Actual pay is set by the research site.

The Methodist Hospital Research InstituteNCT06339320

Phase 2

A Phase 2 Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Narsoplimab in Pediatric Patients (28 Days to ≤ 18 Years of Age.) With High-Risk Hematopoietic Stem Cell Transplant Thrombotic Microangiopathy

The purpose of this study is to evaluate the safety and efficacy of narsoplimab in pediatric patients with thrombotic microangiopathies (TMA) following hematop…

Thrombotic MicroangiopathiesHematopoietic Stem Cell Transplantation

Estimated

~$75 – $2,800

Actual pay is set by the research site.

Omeros CorporationNCT05855083

Phase 3

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Single-attack Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral Ubrogepant in the Acute Treatment of Migraine With or Without Aura in Children and Adolescents (Ages 6-17)

Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting…

Migraine

Estimated

~$50 – $2,250

Actual pay is set by the research site.

AbbVieNCT05125302

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

This is a multi-center, prospective, observational study designed to evaluate the impact of LV myocardial fibrosis extent assessed by CMR on LV reverse remodel…

Heart Failure and Reduced Ejection FractionFunctional Mitral Regurgitation

Estimated

~$10 – $750

Actual pay is set by the research site.

Minneapolis Heart Institute FoundationNCT07131631

Observational

Psycho-Spiritual Management for Patients With Advanced Cancer and Their Family Caregivers

The goal of this behavioral research study is to learn about the effects of two different supportive care programs on patients' and their family caregivers' ps…

Cancer

Estimated

~$10 – $750

Actual pay is set by the research site.

M.D. Anderson Cancer CenterNCT06409065

Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC (TUMORIN)

To test whether it is feasible to perform the 3D-EX functional predictive response bioassay in the context of patients with advanced/metastatic NSCLC receiving…

Lung CancerNSCLCNSCLC Stage IV

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Jun Zhang, MD, PhDNCT05332925