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A 12-Week, Phase 2, Multicenter, Randomized, Double-Masked, Vehicle Controlled, Parallel Group Study With 2 Weeks of Follow-Up to Evaluate the Efficacy and Safety of DFL24498 0.08% Topical Ophthalmic Solution Versus Vehicle in Participants With Dry Eye Disease

This is a Phase 2, randomized, multicenter, double masked, vehicle controlled, parallel group study to evaluate the efficacy and safety of DFL24498 topical oph…

Dry Eye Disease (DED)

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Dompé Farmaceutici S.p.ANCT07503886

Phase 1

Phase I/II Study of the MEK Inhibitor Selumetinib Plus DS-8201a (Trastuzumab Deruxtecan) in KRAS-Mutant, HER2-Expressing Pancreatic Ductal Adenocarcinoma

This phase I/II trial tests the safety, side effects, best dose and how well giving selumetinib with trastuzumab deruxtecan (DS-8201a) works for the treatment …

Advanced Pancreatic Ductal AdenocarcinomaMetastatic Pancreatic Ductal AdenocarcinomaStage III Pancreatic Cancer AJCC v8+2 more

Estimated

~$150 – $2,700

Actual pay is set by the research site.

National Cancer Institute (NCI)NCT07619521

Phase 3

A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2)

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increase…

Type 2 Diabetes Mellitus

Estimated

~$50 – $2,250

Actual pay is set by the research site.

AstraZenecaNCT07662213

Phase 1

Pilot Trial of a Novel, Non-invasive Treatment for Upper-limb Spasticity in People With Spinal Cord Injury

Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause si…

Spinal Cord InjurySpasticityShockwave Therapy

Estimated

~$150 – $3,000

Actual pay is set by the research site.

Kessler FoundationNCT07501429

Observational

Randomized Trial Comparing Next Generation Fluoroscopy System With Conventional Fluoroscopy System in Fluoroscopy-guided Endoscopic Procedures

Fluoroscopy is an integral part of both basic and advanced gastrointestinal endoscopy procedures. Given the risks of radiation exposure and inherent limitation…

Radiation Exposure

Estimated

~$10 – $1,050

Actual pay is set by the research site.

Orlando Health, Inc.NCT07594132

Continuous Assessment of Cerebral Autoregulation in Subarachnoid Hemorrhage (SAH) Patients Using Cerebral Oximetry Index and Hemoglobin Volume Reactivity Index

The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry i…

Subarachnoid Hemorrhage, Aneurysmal

Estimated

~$10 – $750

Actual pay is set by the research site.

University of Alabama at BirminghamNCT06932640

Observational

INSPIRED: Implementation of Novel Strategies to Promote Improvements in Referrals and Engagement for DSMES

A multicomponent implementation strategy bundle designed to improve Diabetes Self-Management Education and Support (DSMES) referral and utilization in rural pr…

Type Two Diabetes Mellitus

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Mary LacyNCT07888179

Phase 1

A Phase 1 Trial to Evaluate the Safety of IL13Rα2-Targeting Chimeric Antigen Receptor (CAR) T Cells With CRISPR Knockout of TGFβR2 in Patients With Recurrent or Progressive High-Grade Glioma (HGG)

This phase I trial tests the safety, side effects and best dose of TGFβR2KO/IL13Rα2 chimeric antigen receptor (CAR) T-cells given within the skull (intracrania…

Recurrent Astrocytoma, IDH-Mutant, Grade 3Recurrent Astrocytoma, IDH-Mutant, Grade 4Recurrent Glioblastoma

Estimated

~$150 – $3,000

Actual pay is set by the research site.

City of Hope Medical CenterNCT06815029

Observational

Is Splinting After Ulnar Nerve Transposition Necessary?

The goal of this clinical trial is to learn whether patient recovery after ulnar nerve transposition (UNT) requires a splint. The main questions it aims to ans…

Ulnar Nerve Transposition

Estimated

~$10 – $750

Actual pay is set by the research site.

University of ChicagoNCT07880470

Observational

Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans

The investigators aim to support care partner's well-being and satisfaction with VA care and decrease their work burden by offering extra support from a traine…

DementiaCancerRenal Disease+1 more

Estimated

~$10 – $675

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT06963970

Phase 3

An Open-label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of 12 Month Treatment With Migalastat in Pediatric Subjects (Aged 2 to < 12 Years) With Fabry Disease and Amenable GLA Variants

An open-label study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of migalastat treatment in pediatric subjects 2 to \< 12…

Fabry Disease

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Amicus TherapeuticsNCT06904261

Observational

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

The goal of this study is to evaluate the effects of transauricular vagus and trigeminal nerve stimulation on the treatment of pain in children with Sickle Cel…

Sickle Cell Disease

Estimated

~$10 – $750

Actual pay is set by the research site.

Emory UniversityNCT07090668