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27,384 recruiting studies available now

Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery

The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding durin…

BleedingColorectal DisordersThromboembolism+1 more

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Kristen BanNCT06657924

Phase 2

A New Intervention to Improve Function in Veterans With Anxiety and Depression

Anxiety and depression symptoms occur at high rates in Veteran populations and can significantly impact function, compromising the ability to work and to succe…

Anxiety and Depression

Estimated

~$75 – $1,800

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT06188923

Phase 1

An Open-Label, Single Injection, Ascending Dose Phase I/II Clinical Study of rAAV9-CMV-hNAGLUop Gene for Patients With Mucopolysaccharidosis (MPS) IIIB

The goal of this clinical trial is to learn if one infusion of rAAV9-CMV-hNAGLUop can treat patients with Sanfilippo syndrome (MPS III) 6 months or older. The …

Sanfilippo Syndrome (MPS III)

Estimated

~$150 – $4,500

Actual pay is set by the research site.

NeuroGTNCT07818759

Phase 3

A Multi-center, Open-label, Single-arm Study to Evaluate the Efficacy and Safety of Oral Rilzabrutinib in Adults With Immune Thrombocytopenia (ITP) Who Failed First-line Treatment

This is a multinational, open label, single arm study that will evaluate the impact of early multi-immune modulation with rilzabrutinib in adult ITP patients w…

Immune Thrombocytopenia

Estimated

~$50 – $2,250

Actual pay is set by the research site.

SanofiNCT07007962

Phase 1

Open-Label, Cohort-Sequential Dose-Escalation and Dose-Confirmation Phase 1/2 Clinical Trial to Evaluate the Safety and Efficacy of Domatinostat in Combination With Sirolimus in Adolescents and Adults With Relapsed, Refractory Sarcoma and Osteosarcoma

This is a multicenter, open-label, Phase 1/2 study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of domatinos…

SarcomaOsteosarcoma

Estimated

~$150 – $3,000

Actual pay is set by the research site.

H. Lee Moffitt Cancer Center and Research InstituteNCT07725380

Phase 2

Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study

This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a …

StrokeStroke, ChronicFatigue

Estimated

~$75 – $1,800

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT05584124

Observational

Supporting Practices In Respecting Elders Phase 2

This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to…

AgingPreventive CareMultimorbidity+1 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Massachusetts General HospitalNCT07166861

Observational

Intercostal Cryoanalgesia in Double Lung Transplant Recipients

This study is testing a new way to help manage pain after a double lung transplant. Instead of relying only on strong pain medicines like opioids, doctors will…

Post-operative Pain Management

Estimated

~$10 – $750

Actual pay is set by the research site.

University of California, Los AngelesNCT07281118

Phase 4

Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty

This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outco…

Osteoarthritis, KneeTotal Knee ArthroplastyChronic Postsurgical Pain

Estimated

~$25 – $1,000

Actual pay is set by the research site.

Vanderbilt University Medical CenterNCT06083480

Phase 1

An Open-Label Phase I Study of JAK Inhibitor Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) is one of the only curative intent therapies available for hematologic malignancies. HLA-matched sibling do…

Graft Vs Host DiseaseGraft-versus-host-diseaseGraft Versus Host Disease

Estimated

~$150 – $3,000

Actual pay is set by the research site.

Washington University School of MedicineNCT06008808

Phase 1

Biologic Validation of Zr-89 Crefmirlimab Berdoxam CD8+ Minibody ImmunoPET in Human Brain Tumors

This phase I trial studies how well zirconium (Zr)-89 crefmirlimab berdoxam and immuno-positron emission tomography (PET) identifies areas of immune cell activ…

GliomaMalignant Brain NeoplasmMeningioma+1 more

Estimated

~$150 – $3,000

Actual pay is set by the research site.

Jonsson Comprehensive Cancer CenterNCT06650163

Leveraging the Exposome and Patient Sensor Data to Enhance Personalized Diabetes Care Across Diverse Communities

The study aims to integrate various data types, such as electronic health records, wearable device data, and environmental data, to create a comprehensive, per…

Type 2 Diabetes

Estimated

~$10 – $750

Actual pay is set by the research site.

University of Illinois at ChicagoNCT06989008