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A Phase 2 Study of Microsatellite Stable Colorectal Cancer (Stage 2 or 3) With Radiographic Occult Molecular Residual Disease Treated With Botensilimab (AGEN1181; Bot) Plus Balstilimab (AGEN2034, Bal) After Established Definitive Therapy (COMBAT Study)

This phase II trial tests the effect of the botensilimab in combination with balstilimab in treating patients with stage II/III colorectal adenocarcinoma with …

Colorectal AdenocarcinomaStage II Colorectal Cancer AJCC v8Stage III Colorectal Cancer AJCC v8

Estimated

~$75 – $1,800

Actual pay is set by the research site.

National Cancer Institute (NCI)NCT07551596

Observational

Comparative Effectiveness of Primary Care Providers Trained in Rheumatoid Arthritis Management Versus Rheumatologist Care: A Randomized Controlled Trial

Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the jo…

Rheumatoid Arthritis (RA

Estimated

~$10 – $750

Actual pay is set by the research site.

St. Lawrence Health SystemNCT07034196

Retina BioBank: Retina Biomarkers for a Deeper Understanding of Vitreoretinal and Systemic Diseases

The RBBK study is a non-interventional, prospective study that will characterize disease state biomarker levels from aqueous humor, vitreous humor, intraoperat…

Other Retinal DisordersRetinal DiseaseRetinal Vascular Disorder

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Greater Houston Retina ResearchNCT06796673

Phase 4

MIRACLE-T2D Montelukast Intervention for Renal, Cardiovascular and Eye Health in Type 2 Diabetes

Diabetes mellitus type 2 is associated with significant morbidity and mortality; and identifying new treatments for diabetes complications to be used alone or …

DiabetesKidney DiseaseVascular Disease+1 more

Estimated

~$25 – $1,000

Actual pay is set by the research site.

University of Colorado, DenverNCT07685886

Autonomic Control and Vascular Function in Type 1 Diabetes

The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answ…

Type 1 Diabetes (Juvenile Onset)Type 1 DiabetesDiabetes, Autoimmune

Estimated

~$10 – $750

Actual pay is set by the research site.

University of Texas at AustinNCT06786546

Phase 2

A Randomized Phase 2, Open-label Study of Mirvetuximab Soravtansine in Patients With Platinum-resistant Advanced High-grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-alpha Expression Testing 2 Schedules of Administration for Dose Optimization, With a Separate Cohort to Determine Starting Dose in Patients With Moderate Hepatic Impairment

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess the safety and efficacy …

Advanced High-Grade Epithelial Ovarian CancerPrimary Peritoneal CancerFallopian Tube Cancers

Estimated

~$75 – $3,000

Actual pay is set by the research site.

AbbVieNCT06682988

Phase 1

A Phase 1/2 Open-label Intrathecal Administration of MELPIDA to Determine Its Safety and Efficacy for Patients With Spastic Paraplegia Type 50 (SPG50) Caused by Mutation in the AP4M1 Gene.

MELPIDA is proposed for the treatment of subjects with SPG50 and targets neuronal cells to deliver a fully functional human AP4M1 cDNA copy via intrathecal inj…

Spasticity, MuscleMicrocephalyIntellectual Deficiency+3 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Elpida Therapeutics SPCNCT05518188

Observational

Modulating Locomotor-Respiratory Coupling Through Adaptive Exoskeleton Assistance in Patients With COPD

1\) Purpose: To improve pulmonary rehabilitation outcomes for individuals with COPD by evaluating the effectiveness of a hip-assisted exoskeleton during a sing…

COPD (Chronic Obstructive Pulmonary Disease)

Estimated

~$10 – $750

Actual pay is set by the research site.

University of NebraskaNCT07703527

Phase 1

The Impact of Phosphate Metabolism on Healthy Aging

Determine the association between duration and dose of chronic conventional therapy with Pi and renal (nephrocalcinosis/nephrolithiasis), vascular (endothelial…

HypophosphatemiaRicketsHypercalciuria+2 more

Estimated

~$150 – $3,000

Actual pay is set by the research site.

Yale UniversityNCT03771105

Observational

Thermogenic Responses to Fasting and Overfeeding in Women: a Potential Mechanism Contributing to Postmenopausal Weight Gain

This study plans to learn more about why menopause increases the risk of weight gain. During and after menopause, women are prone to increased weight gain. The…

Obesity

Estimated

~$10 – $750

Actual pay is set by the research site.

University of Colorado, DenverNCT06610162

Phase 2

Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

Chronic pain symptoms are very common among U.S. Military Veterans and have a profound negative impact on mental health symptoms and quality of life, in additi…

Chronic Low Back Pain

Estimated

~$75 – $1,800

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT05935761

Phase 3

A Multicenter, Randomized, Controlled, Open-label, Group-Sequential, Phase 3 Study to Investigate the Efficacy, Safety, and Tolerability of Intravenous Gammagard Liquid (Immune Globulin Infusion, 10%) for Primary Infection Prophylaxis Compared With Secondary Infection Prophylaxis in Adult Subjects With Multiple Myeloma Receiving B-Cell Maturation AntigenxCD3-Directed Bispecific Antibody Therapy

Multiple myeloma is a cancer of the plasma cells in the bone marrow. The main aim of this study is to learn how well the Immune Globulin Infusion (human), 10 …

Multiple MyelomaSecondary Immunodeficiency

Estimated

~$50 – $2,250

Actual pay is set by the research site.

TakedaNCT06980480