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A Phase 1/2, Open-Label, Multi-Center, Dose Escalation, Dose Expansion, and Single Repeat Dose Study of TSRA-196 in Adults With the PiZZ Genotype Who Have Lung and/or Liver Disease Associated With Severe Alpha-1 Antitrypsin Deficiency

This is a Phase 1/2, open-label, multi-center, dose escalation (Part 1), dose expansion (Part 2), and single repeat dose (Part 3) study to evaluate the safety,…

Alpha-1 Antitrypsin Deficiency (AATD)

~$10 – $8,750

Tessera Therapeutics, Inc.NCT07227207

The Role of Conformational Diseases on Macrophage Function

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macroph…

Alpha-1 Antitrypsin DeficiencyAAT DeficiencyAATD+1 more

University of FloridaNCT01851642