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3,218 recruiting studies matching your filters

Molecularly-Guided Phase II Umbrella Trial for Children, Adolescents, and Young Adults Newly Diagnosed With High-Grade Glioma, Including Diffuse Intrinsic Pontine Glioma

The goal of this study is to perform genetic sequencing on brain tumors from children, adolescents, and young adult patients who have been newly diagnosed with…

High Grade GliomaDiffuse Intrinsic Pontine GliomaAnaplastic Astrocytoma+6 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Nationwide Children's HospitalNCT05839379

Phase 3

An Efficacy and Safety, Phase III, Multi-center, Double-Blind, Randomized Controlled Study Comparing 2 Active Doses of CYB003 and Placebo in Eligible Participants With Major Depressive Disorder

The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with…

Major Depressive Disorder (MDD)Depression in AdultsDepression - Major Depressive Disorder+3 more

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Cybin IRL LimitedNCT06793397

Phase 2

Endovascular Infusion of Lidocaine and Steroids in the Middle Meningeal Artery for Pain Management in Spontaneous Subarachnoid Hemorrhage Patients

The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe …

Subarachnoid Hemorrhage, AneurysmalHeadacheOpiate Dependence+1 more

Estimated

~$75 – $2,000

Actual pay is set by the research site.

The University of Texas Medical Branch, GalvestonNCT07294118

Phase 1

A Phase 1/2, Open Label, Dose-escalation, and Dose-expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Recommended Phase 2 Dose of D3S-002 Monotherapy or Combination Therapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations

This first-in-human (FIH) study aims to assess the safety, tolerability, pharmacokinetics, and recommended phase 2 dose (RP2D) of D3S-002 given orally daily fo…

Advanced Solid Tumors With MAPK Pathway Mutations

Estimated

~$150 – $4,200

Actual pay is set by the research site.

D3 Bio (Wuxi) Co., LtdNCT05886920

Observational

Mobile Video Directly Observed Therapy (DOT) for Immunosuppression Medication Adherence in Adolescent Heart Transplant Recipients: Enhancing Technological Innovation and Strengthening the Role of Small Businesses in Meeting Needs of Adolescent Organ Transplant

We will conduct a two-group randomized controlled trial to examine the eMocha DOT intervention with pediatric HT recipients.In this population, medication nona…

Heart Transplant RejectionImmune SuppressionPediatric Heart Transplant+4 more

Estimated

~$10 – $750

Actual pay is set by the research site.

University of FloridaNCT05732779

Observational

Sequencing-guided cHemotherapy Optimization Using Real-Time Evaluation in Newly Diagnosed DLBCL With Circulating Tumor DNA: SHORTEN-ctDNA

The purpose of this study is to 1) determine whether it is feasible to measure circulating tumor DNA (ctDNA) in real-time during standard treatment for newly d…

LymphomaLymphoma, B-CellDiffuse Large B Cell Lymphoma+2 more

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Hua-Jay J Cherng, MDNCT06693830

Phase 2

Tryptophan-kynurenine Pathway PET Imaging in Human Gliomas

The goal of this clinical trial is to evaluate Positron emission tomography/computed tomography (PET/CT) imaging with the radiotracer 1-(2-\[18F\]fluoroethyl)-…

Low Grade GliomaGlioblastoma

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Barbara Ann Karmanos Cancer InstituteNCT07735819

Phase 3

An Open-Label, Multicenter Study to Evaluate the Pharmacokinetics and Safety of XEMBIFY Versus Gamunex-C in Participants With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

The main goal of the study is to find out whether XEMBIFY, given once a week under the skin, provides similar levels of immunoglobulin G in the blood over time…

CIDP (Chronic Inflammatory Demyelinating Polyradiculoneuropathy)

Estimated

~$50 – $2,100

Actual pay is set by the research site.

Grifols Therapeutics LLCNCT07540221

Phase 3

A Phase III, Randomized, Open-Label, Multi-Center, Global Study of Volrustomig (MEDI5752) as Sequential Therapy Versus Observation in Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma, Who Have Not Progressed Following Definitive Concurrent Chemoradiotherapy (eVOLVE-HNSCC)

The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced hea…

Locally Advanced Head and Neck Squamous Cell Carcinoma

Estimated

~$50 – $2,250

Actual pay is set by the research site.

AstraZenecaNCT06129864

The Seaver Autism Center for Research and Treatment - Assessment Core

ADNP, also known as Activity Dependent Neuroprotective Protein, is a rare neurodevelopmental disorder caused by mutations encompassing the ADNP gene on chromos…

ADNPHelsmoortel-Van Der Aa SyndromeAutism Spectrum Disorder

Estimated

~$10 – $750

Actual pay is set by the research site.

Icahn School of Medicine at Mount SinaiNCT03718936

Phase 1

A Phase I/II, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activities of CS2009, a Tri-specific Antibody Targeting PD-1/VEGFA/CTLA-4, as Monotherapy and Combination Therapy in Participants With Advanced Solid Tumors

This is a first-in-human (FIH), open-label, and multi-center Phase I/II study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary …

Advanced Solid Tumors

Estimated

~$150 – $4,200

Actual pay is set by the research site.

CStone PharmaceuticalsNCT06741644

Observational

Laparoscopically Harvested Omental Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)

This single center, single arm, open-label, phase I study will assess the safety of laparoscopically harvested autologous omentum, implanted into the resection…

GliomaGlioma, MalignantGlioblastoma+5 more

Estimated

~$10 – $1,125

Actual pay is set by the research site.

Northwell HealthNCT05979064