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1,237 recruiting studies matching your filters

A First-In-Human, Phase 1, Open-Label, Multicenter Study of ZW251, a Novel Glypican-3 Targeting Antibody-Drug Conjugate, in Participants With Advanced Solid Tumors, Including Hepatocellular Carcinoma

The purpose of this study is to find out if ZW251, an antibody-drug conjugate targeting glypican-3 (GPC3), is safe and can treat participants with advanced can…

Hepatocellular CarcinomaSquamous Cell Non-Small Cell Lung CancerGerm Cell Tumor

Estimated

~$10 – $8,750

Zymeworks BC Inc.NCT07164313

Phase 2

A Phase II Trial of Trifluridine/Tipiracil Plus Oxaliplatin in Patients With Advanced or Metastatic Biliary Tract Cancer Following First-Line Therapy

Participants are eligible for this study who were treated for advanced biliary tract cancer (BTC) but the treatment either did not make the cancer better or is…

Biliary Tract CancerBiliary Tract NeoplasmsCholangiocarcinoma+2 more

Estimated

~$10 – $6,250

Case Comprehensive Cancer CenterNCT07146646

Phase 1

A First-in-Human, Open-label, Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With Advanced-Stage, Relapsed/Refractory HER3-Expressing Solid Tumors

This study is a Phase 1/2, first-in-human, open-label, clinical trial to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of HMBD-501…

Melanoma (Skin)Non Small Cell Lung CancerBreast Cancer

Estimated

~$10 – $7,500

Hummingbird BioscienceNCT06956690

Phase 2

A Phase II Study of BIO 300 to Reduce the Toxicity of Thoracic Radiotherapy for Patients With Early-Stage Non-Small Cell Lung Cancer and Interstitial Lung Disease (BREATHE)

The purpose of this study to find out whether giving BIO 300 in combination with thoracic radiation therapy is effective in preventing pneumonitis in people wi…

NSCLCNSCLC, Stage INSCLC Stage II+5 more

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT07323732

Observational

Older Adult Traditional Balance Training vs Traditional Balance Training Plus Neck Strengthening

This study promotes greater understanding of factors impacting balance and how neck strength alters specific aspects of impaired balance. This study will help …

AgingFall Injury PreventionAt Fall Risk

Estimated

~$10 – $6,250

Ohio UniversityNCT07503899

Observational

A Family-Based HIV Prevention Program for Black Men to Protect Black Girls

The scientific premise of this research is that individual, interpersonal, and structural factors impact Black girls' sexual reproductive health outcomes (sexu…

Sexually Transmitted Infections (Not HIV or Hepatitis)HIV InfectionsSexual Behavior

Estimated

~$10 – $6,250

University of Illinois at ChicagoNCT06266416

Phase 1

Phase 1a/1b Dose Escalation and Cohort Expansion Study of the Safety and Efficacy of B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells (MC10029) in Subjects With Relapsed or Refractory BAFFR-Expressing B-Cell Hematologic Malignancies

This phase I trial tests safety, side effects and best dose of B-cell activating factor receptor (BAFFR)-based chimeric antigen receptor T-cells, with fludarab…

B-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Diffuse Large B-Cell Lymphoma+12 more

Estimated

~$10 – $6,250

GSD VI and GSD IX Natural History

Collection and review of clinical information related to Glycogen Storage Disease Type VI (GSD VI) OR Glycogen Storage Disease Type IX (GSD IX) generated durin…

Glycogen Storage Disease VIGLYCOGEN STORAGE DISEASE IXa1GLYCOGEN STORAGE DISEASE IXa2+4 more

Estimated

~$10 – $750

Duke UniversityNCT04454216

Phase 2

A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus

This study is to collect safety and immunogenicity data for an Rift Valley Fever (RVF) vaccine

Rift Valley Fever

Estimated

~$10 – $5,625

U.S. Army Medical Research and Development CommandNCT03609398

Observational

Improving Chemotherapy-induced Nausea Control Through Bright Ideas®-CIN Training: a Feasibility Study in Children Receiving Oral Chemotherapy

In this study investigators will determine the feasibility of a future trial comparing chemotherapy-induced nausea control in children with ALL receiving oral …

Acute Lymphoblastic Leukemia (ALL)

Estimated

~$10 – $6,250

The Hospital for Sick ChildrenNCT04929899

Phase 1

A Phase 1/2, Multicenter, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Antitumor Activity of TNG456 Monotherapy and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP l…

Non Small Cell Lung CancerGlioma Glioblastoma MultiformeGlioma, Malignant+4 more

Estimated

~$10 – $8,750

Tango Therapeutics, Inc.NCT06810544

I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy

I3LUNG is an international project aiming to develop a medical device to predict immunotherapy efficacy for NSCLC patients using the integration of multisource…

Non Small Cell Lung CancerLung Cancer MetastaticLung Cancer, Nonsmall Cell+1 more

Estimated

~$10 – $1,125

Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoNCT05537922