The goal of this observational study is to learn how well a multimodal "Progression and Risk" (PR) model can predict and stage early mild cognitive impairment …

Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)Alzheimer Disease (AD)+1 more

~Estimated

~$10 – $1,050

Prevention Research Consortium Corp.NCT07516119

Phase 1

Effects of Sirolimus on Middle Aged Asymptomatic ApoE4 Carriers

Alzheimer's disease is a devastating neurodegenerative disease characterized by accumulation of clumps (also called plaques) and bundles of fibers (also called…

Genetic Predisposition to DiseaseHealthy VolunteerAPOE-4 Positive

~Estimated

~$10 – $6,250

University of Missouri-ColumbiaNCT07728175

Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study

This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield …

Alzheimer's DiseaseMild Cognitive ImpairmentParkinson's Disease+12 more

~Estimated

~$10 – $750

Duke UniversityNCT03233646