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A First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of HMB-003 in Healthy Volunteers

The purposes of this clinical study are 1. To see how the new drug (HMB-003) under study is tolerated in healthy volunteers, and if there are any important si…

Healthy Adult Participants

Randomized Trial to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Heart Failure Patients With Left Ventricular Ejection Fraction Greater Than or Equal to 40% Hospitalized Due to an Episode of Acute Decompensated Heart Failure (REDEFINE-HF)

Finerenone will be compared to placebo to determine efficacy and safety of treatment in patients hospitalized with acute decompensated heart failure (HF) and m…

Heart FailureAcute Heart Failure

Estimated

~$10 – $7,500

Colorado Prevention CenterNCT06008197

Phase 1

A Multiple-Center Study to Evaluate the Skin Irritation and Sensitization Potential of a Test Estradiol/Levonorgestrel Transdermal Delivery System (Corium TDS)

The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System …

MenopauseHealthy Female Participants

Estimated

~$10 – $8,750

Corium Innovations, Inc.NCT07794150

Phase 3

Randomized Trial on the Evaluation of the Effectiveness of One Single Bone Marrow Aspirate Hip Injection Versus Triamcinolone for Hip Osteoarthritis

This is a single site, randomized single blinded, two arm study researching the effects of bone marrow aspirate concentrate (BMAC) versus Triamcinolone in pati…

Hip Osteoarthritis

Estimated

~$10 – $6,250

The Cleveland ClinicNCT04990128

Phase 4

Biomarkers in Management of PP Preeclampsia

Participants are recruited for a research study about how lab values change following delivery in people with Preeclampsia with Severe Features. Preeclampsia w…

Preeclampsia SeverePreeclampsia Postpartum

Estimated

~$10 – $7,500

Alexander HarrisonNCT07478055

Observational

Efficacy of Self-Administered Percussive Massage Therapy Versus Gentle Manual Massage to the Thigh Following Anterior Total Hip Arthroplasty: A Prospective Randomized Controlled Trial

Many people who have hip replacement surgery through a "bikini incision" on the front of the hip (anterior approach) develop numbness, tingling, burning, or ti…

ParesthesiaTotal Hip Arthroplasty (THA)Direct Anterior Total Hip Arthroplasty+1 more

Estimated

~$10 – $7,500

Zachary M RicciardelliNCT07790705

Phase 3

A Multi-Center, Randomized, Double-Blind, and Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Stratified by Prior Biologic Use (LATITUDE-PsA-3002)

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is …

A Pragmatic Randomized Pilot Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial Spondyloarthritis

The purpose of this study is to determine the feasibility of conducting a pragmatic trial of IL-17i versus JAKi in adults with axial spondyloarthritis (axSpA) …

Axial Spondyloarthritis (AxSpA)

Estimated

~$10 – $6,250

The University of Texas Health Science Center, HoustonNCT07770646

Phase 3

A Phase 3, Multicenter, Long-Term Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Who Are Either Biologic DMARD-Naïve or Biologic DMARD-Experienced, Including Those With Inadequate Response to Biologic DMARDs

Psoriatic arthritis (PsA) is a long-term inflammatory disease that affects the joints and skin. The purpose of this study is to check how safe zasocitinib is,…

Community-based Exercise to Improve Physical Functioning and Cardiovascular Health Following Revascularization for Peripheral Artery Disease

The primary goal of this clinical trial is to evaluate whether a community-based structured exercise therapy (CB-SET) intervention, which could be accessible a…

Peripheral Artery Disease

Estimated

~$10 – $6,250

University of MinnesotaNCT04252950

Echocardiographic Assessment of the Effect of Impella on Biventricular Function

The objective of this prospective observational study is to evaluate the effects of Impella 5.5 on biventricular function in adult patients with end-stage hear…

End-stage Heart Failure

Estimated

~$10 – $750

University of RochesterNCT07534462

Phase 2

A Double-blind, Phase II Randomized Study of Brain-directed Stereotactic Radiation With or Without AGuIX Gadolinium-based Nanoparticles in the Management of Brain Metastases at Higher Risk of Local Recurrence With Radiation Alone

The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work mo…

Brain CancerBrain MetastasesMelanoma+13 more

Estimated

~$10 – $6,250

Brigham and Women's HospitalNCT04899908