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Phase 1
A Pilot Study of the Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
This will be a single center, randomized, double-blind, placebo-controlled pilot study to assess the safety and tolerability of terazosin (TZ) at a dose of 5 m…
Amyotrophic Lateral SclerosisAdenosine Triphosphate Activities
University of IowaNCT07224269
Phase 1
Efficacy and Safety of Cryopreserved Autologous Mobilized Peripheral Blood CD34+ HSPCs Transduced Ex Vivo With the EFS-ADA Lentiviral Vector in Patients With Severe Combined Immune Deficiency Due To Adenosine Deaminase Deficiency
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from mobilized peripheral bl…
Adenosine Deaminase Severe Combined Immune Deficiency
University of California, Los AngelesNCT05432310
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients With Sickle Cell Disease
Background: Some people with the same disorder on a genetic level have more complications than others. Researchers want to look for a link between the PKLR ge…
Sickle CellPKLR VariantsAdenosine Triphosphate Activities
National Heart, Lung, and Blood Institute (NHLBI)NCT03685721
Phase 4
Measure Striatal Adenosine-dopamine Receptors Interactions: from Molecule to Behaviors
This research study aims to determine whether and how caffeine intake affects learning process through reward feedback compared to placebo. The data acquired f…
HealthyCaffeineAdenosine+1 more
Hsiao-Ying WeyNCT06763172