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Optimizing Strength Training in Older Adults
The objective of the current study is to determine whether lifting lighter loads close to failure improves strength training adaptations and function in older …
Losing Specificity: the Role of the Locus Coeruleus in Age-related Distractibility
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentio…
Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older Adults
Participants in this study will undergo a series of non-invasive tests and activities designed to understand how a single dose of psilocybin might influence co…
Evaluating the Disease Modifying Potential of a Sleep Intervention on Alzheimer's Disease (AD) Biomarkers
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function …
Fatty Acid Modulation of Brain Function in Older Adults
In this crossover study, the investigtors will administer two experimental diets in a random order for one week, and each experimental diet will be preceded by…
Modulation of the Gut Microbiome by Dietary Fiber to Improve Calcium Absorption and Bone Health in Older Men
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for …
A Pilot Study of a Portable Head-Only MRI Scanner
This is a pilot study to demonstrate human brain imaging with a new portable 0.7 Tesla (T) MRI brain scanner recently developed at the CMRR.
Web-based Technology and Cognitive Training: Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related co…
Molecular Indicators of Systematic Fitness
The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements…
Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults
Age-related declines in motor function can compromise independence and quality of life. This project examines how practice and somatosensory stimulation reshap…
Robotically Assisted Anterior Eye Examinations for Acute Eye Care
The purpose of this study is to develop and test a robotically assisted imaging system for the front of the eye with a goal of helping eye care through the eme…
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and Mild Cognitive Impairment
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.