Find your next paid study

University of MiamiNCT05991713

Phase 1

Targeting Reward Circuits: Psilocybin as a Novel Therapy for Residual Anhedonia

This study is for adults with major depressive disorder (depression) who are currently taking an SSRI or SNRI antidepressant but continue to experience anhedon…

AnhedoniaEmotional Blunting

NYU Langone HealthNCT07607938

~$10 – $7,500

Phase 1

A Double Blind, Randomized Trial Investigating the Safety, Feasibility, and Mechanisms of Psychedelics in Healthy Older Adults With Low Well-being as Moderated by Biomarkers for Preclinical Alzheimer's Disease

This study is being conducted to understand changes in brain activity following administration of two different drugs (Psilocybin and Dextromethorphan) in olde…

Anhedonia in Healthy VolunteersOlder Adults (50-90 Years)

Jennifer MitchellNCT07386730

~$10 – $7,500

Major Depressive DisorderAnhedonia

Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression

Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated…

Florida State UniversityNCT06132581

Multimodal Differences in Effort-based Decision-Making in Depression - - Brain Behavior Quantification and Synchronization

Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts o…

DepressionAnhedonia

Georgia Institute of TechnologyNCT06648460

Suicidal IdeationSuicidalSuicidal Thoughts+3 more

Pilot Development of a Youth-Focused Digital Just-in-Time Adaptive Intervention to Enhance Reward Sensitivity and Reduce Suicidal Ideation

The goal of this clinical trial is to develop and test an app designed to reduce suicide risk and improve emotional well-being in adolescents. The study will t…

University of PennsylvaniaNCT07661901

AnhedoniaStress ResponseAdolescent Development

Stress Trajectories and Anhedonia in Adolescence Research Study

This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) …

University of North Carolina, Chapel HillNCT07040449

SuicideMental Health DisorderAnhedonia

BRITE 2.0: A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents (ViraSafe RCT (SBIR Phase 2))

Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Digital tools, especially personal s…

~$10 – $7,500

Ksana HealthNCT07348666

Social AnhedoniaSocial Function Impairment

Clinical and Neurocomputational Effects of Behavioral Activation in Veterans With Impaired Social Functioning

Poor psychosocial functioning, including social disconnection, is common and disabling among Veterans, and often fails to improve following the best available …

VA Office of Research and DevelopmentNCT07697001

~$10 – $5,625

Phase 2

The Role of Inflammation in Central Nervous System (CNS) Mechanisms of Anhedonia and Psychomotor Slowing in Depressed People With HIV

The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribut…

HIVDepressionAnhedonia

Emory UniversityNCT05849038

AnhedoniaDepression and Suicide Ideation

Geospatial and Ecological Momentary Assessment Technology and Activity Engagement for At-risk Youth (Get ActivE)

The study will adapt and deploy a digital Behavioral Activation app with mobile sensing, supported by health coaches, that encourages youth to engage in positi…

University of PittsburghNCT06829953

Phase 4

Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis

This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function u…

DepressionPsychosisAnhedonia