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Phase 4
Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression
This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depressio…
Depression, AnxietyFearDepression+3 more
Laureate Institute for Brain Research, Inc.NCT06004115
Phase 4
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam…
Anxious DepressionDepression
University of CincinnatiNCT04245748