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333 recruiting studies matching your filters

A Phase 1/2a, Open-label, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of BMS-986528 in Participants With Refractory Rheumatoid Arthritis

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary evidence of disease-modify…

Arthritis, Rheumatoid

Estimated

~$10 – $7,500

Bristol-Myers SquibbNCT07412704

Phase 3

A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY384…

OsteoarthritisOverweight or Obesity

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT07353931

Observational

Confirmation of Values and Preferences When Considering a Musculoskeletal Diagnostic Test: A Scenario-Based Study

The goal of this clinical trial is to understand how people make decisions about imaging tests for common musculoskeletal problems (like arthritis, tendon prob…

Non-traumatic Musculoskeletal ConditionsCarpal Tunnel Syndrome (CTS)Lateral Epicondylitis+5 more

Estimated

~$10 – $6,250

University of Texas at AustinNCT07158892

Phase 2

A Phase 2, Multicenter, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderately to Severely Active Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy…

A Phase II, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response or Intolerance to TNF and/or JAK Inhibitors

This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid…

Rheumatoid Arthritis

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT07137598

Observational

IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success

Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patient…

Knee OsteoarthritisKnee DiscomfortKnee Pain Chronic+1 more

Estimated

~$10 – $7,500

Lucas R. Cusumano, MDNCT07494838

Observational

Safety and Effectiveness of the Hip Innovation Technology Reverse Hip Replacement System in Primary Total Hip Arthroplasty: A Pivotal Study

The purpose of this study is to determine if the use of the HIT Reverse Hip Replacement System is safe and effective in patients undergoing total hip replaceme…

Degenerative Joint DiseaseOsteoarthritis, HipAvascular Necrosis of Hip+1 more

Estimated

~$10 – $7,500

Hip Innovation TechnologyNCT05357378

Phase 1

An Open-label, Phase I Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Surovatamig Following Single-ascending Dose and Step-up Dose Administration to Adult Participants With Rheumatoid Arthritis or Systemic Lupus Erythematosus

This open-label, Phase I study will assess the safety and tolerability of surovatamig and characterise its PK and PD following subcutaneous administration to p…

Rheumatoid ArthritisSystemic Lupus Erythematosus

Estimated

~$10 – $7,500

AstraZenecaNCT07201558

Phase 2

An Extension Study to Evaluate the Long-term Safety and Efficacy of Afimkibart (RO7790121) in Patients With Rheumatoid Arthritis Who Participated in Previous Afimkibart Clinical Trials

The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis …

Rheumatoid Arthritis

Estimated

~$10 – $7,500

Hoffmann-La RocheNCT07620392

Phase 1

A Multicenter Open-label, Prospective Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)

Primary purpose of the study is to assess the concentration of bimekizumab in mature human breast milk.

Moderate to Severe Plaque PsoriasisPsoriatic ArthritisAxial Spondyloarthritis+1 more

Estimated

~$10 – $8,750

UCB Biopharma SRLNCT06888193

Phase 3

A Multi-Center, Randomized, Double-Blind, Placebo- and Active-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Who Are Naïve to Biologic Disease-Modifying Antirheumatic Drugs (LATITUDE-PsA-3001)

Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the joints and skin in people who have psoriasis (PsO). The main aim of the study is …

An Open Label, Multi-Center, Retrospective and Prospective Evaluation of Shoulder Arthroplasty Clinical and Radiographic Outcomes

The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performan…

Osteo Arthritis ShouldersOsteonecrosisRotator Cuff Tears+6 more

Estimated

~$10 – $1,125

ExactechNCT05603728