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Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
Background: Disorders of hearing instability (HI) are poorly characterized and ineffectively treated. HI can cause fluctuations in hearing thresholds and spee…
Meniere's DiseaseEnlarged Vestibular Aqueduct SyndromeAutoimmune Inner Ear Disease
Estimated
~$10 – $675
National Institute on Deafness and Other Communication Disorders (NIDCD)NCT04806282
Phase 2
A Phase II Placebo Controlled Study of the Effects of Anakinra (Kineret) in Subjects With Corticosteroid-Resistant/Intolerant Meniere's Disease (CR-MD) and Corticosteroid-Resistant/Intolerant Autoimmune Inner Ear Disease Disease (CR-AIED)
A Phase II randomized, placebo controlled study design of anakinra (Kineret) in corticosteroid-resistant or intolerant Meniere's disease (CR-MD)and corticoster…
Autoimmune Inner Ear DiseaseMeniere's Disease
Estimated
~$10 – $7,500
Northwell HealthNCT03587701