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Phase 2
A Phase 2a Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients
Background: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of the immune system caused by a mutation in the FAS gene. In ALPS, the body sto…
Autoimmune Lymphoproliferative Syndrome
National Institute of Allergy and Infectious Diseases (NIAID)NCT06730126
Phase 2
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity
Background: During a transplant, blood stem cells from one person are given to someone else. The cells grow into the different cells that make up the immune s…
Lymphoproliferative DisordersAutoimmune LymphoproliferativeImmune System Diseases+2 more
National Cancer Institute (NCI)NCT04339777
Phase 2
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers…
Primary T-cell Immunodeficiency DisordersCommon Variable ImmunodeficiencyImmune System Diseases+2 more
National Cancer Institute (NCI)NCT02579967
Phase 2
Phase 2 Study BRIDGING PRE-TRANSPLANT INFLAMMATORY DAMPENING for PRIMARY IMMUNE REGULATORY DISORDERS (BRIDGE Trial)
The researchers are doing this study to find out whether emapalumab or a combination of fludarabine and dexamethasone are effective in preparing people with a …
Primary Immune Regulatory DisorderAutoimmune LymphoproliferativeImmune System Diseases
Memorial Sloan Kettering Cancer CenterNCT05787574