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Phase 1
A Phase I/Ib Study of Olaparib and ASTX727 in BRCA1/2- and HRD-mutated Tumors
This is a single center, phase I/Ib clinical trial evaluating the combination of the poly adenosine diphosphate-ribose polymerase (PARP) inhibitor olaparib wit…
BRCA1 MutationBRCA2 MutationBRCA Mutation+3 more
Pamela MunsterNCT06177171
Phase 1
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
This is a two-part, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pha…
Advanced or Metastatic Solid TumorsBreast CancerOvarian Cancer+10 more
858 Therapeutics, Inc.NCT06395519