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Treatment of Brain AVMs (TOBAS) Study: A Randomized Controlled Trial and Registry
The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unr…
Effects of Rehabilitation Following Traumatic Brain Injury and Stroke: A Long Term Outcome Study.
Investigators will determine the long-lasting effects of post-acute rehabilitation after traumatic brain injury and stroke. Investigators will also evaluate if…
Community-based Implementation of an Emotion Regulation Intervention for Individuals With Traumatic Brain Injury
This is a hybrid type III implementation-effectiveness trial; this study design blends elements of implementation and clinical effectiveness research, with the…
Feasibility of a Digital Art Therapy Application Designed to Improve Quality of Life in Young Cancer Survivors
This is a single-site, single-arm, interventional study assessing the feasibility of the ARTCan Therapy Application (App) and whether it is an acceptable means…
Pilot Study for Non-invasive Glioma Characterization Through Molecular Imaging
MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and he…
Evaluation of Decision-Making Fatigue After Traumatic Brain Injury (EDIFY)
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic…
A Prospective, Non-randomized, Sequentially-enrolled, Multi-center, Phase II Study to Evaluate the SENSE Device's Ability to Detect Traumatic Brain Injury
The study population will consist of 3 mutually-exclusive sets of patients and subjects: * TBI patients with intracranial bleeding * TBI patients without intr…
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS…
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Investigators propose to develop hyperpolarized \[13C\]-labeled pyruvate as potential imaging probes to assess two essential in vivo processes in cerebral meta…
Noninvasive Vagus Nerve Stimulation for Improved Speech in Noise Perception
Traumatic brain injury, a common injury in military service personnel, often leads to poor processing of speech in noisy environments. The goal of the current …
Precision Radiotherapy Enabled by Molecular MRI
This is a research study to determine if a novel molecular magnetic resonance imaging (MRI) technique, called amide proton transfer (APT) imaging, is useful in…
A Phase 1/1b Study of Autologous b7-h3 Chimeric Antigen Receptor t Cells (b7-h3.cd28z.Cart) in Children and Young Adults With Recurrent or Progressive Cns Neoplasms Expressing b7-h3 Target
The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or…