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6 recruiting studies matching your filters

A Phase 3, Open-label, Randomized, Standard of Care-controlled, Parallel Study Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) Progression in Participants With a Bilateral Lung Transplant

The goal of this Phase 3 clinical trial is to compare ARINA-1 (a nebulized immunomodulatory agent) plus Standard of Care vs Standard of Care alone. The main qu…

Pre-Bronchiolitis Obliterans Syndrome

Estimated

~$10 – $8,750

Renovion, Inc.NCT05654922

Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD

This study is for people who have had a lung transplant and developed a condition called chronic lung allograft dysfunction (CLAD), which is a type of chronic …

Lung Transplant Failure and RejectionCLAD, Bronchiolitis ObliteransExtracorporeal Photopheresis

Estimated

~$10 – $1,125

Brian KellerNCT07434869

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Ea…

Hematopoietic Stem Cell Transplant (HSCT)Diffuse Alveolar HemorrhageThrombotic Microangiopathies+2 more

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT04098445

Phase 2

A Randomized, Placebo-controlled Phase 2 Study to Demonstrate the Safety and Efficacy of the Addition of LAM-001 to Standard Immunosuppression Therapy for Chronic Lung Allograft Dysfunction (BOS).

The goal of this clinical trial is to learn about the safety and effectiveness of LAM-001 in patients who have developed bronchiolitis obliterans syndrome (BOS…

Bronchiolitis Obliterans SyndromeChronic Lung Allograft DysfunctionLung Transplantation

Estimated

~$10 – $7,500

Steven Hays, MDNCT06018766

Phase 2

An Open-Label, Phase 2 Study to Evaluate the Activity of Belumosudil in Subjects With New Onset and Incipient Bronchiolitis Obliterans Syndrome Following Allogeneic Hematopoietic Cell Transplantation

The goal of this research study is to test the efficacy of a novel immunosuppressive agent, belumosudil, in allogeneic hematopoietic stem cell transplant (HSCT…

Bronchiolitis Obliterans SyndromeBronchiolitis ObliteransLung Diseases+1 more

Estimated

~$10 – $7,500

Dana-Farber Cancer InstituteNCT05922761

Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome

This study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor s…

Bronchiolitis Obliterans

Estimated

~$10 – $750

M.D. Anderson Cancer CenterNCT04604522