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Phase 1
Pharmacokinetics, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia
The purpose of the study is to learn how safe montelukast may be in premature infants at significant risk for Bronchopulmonary Dysplasia (BPD) and to determine…
Bronchopulmonary Dysplasia (BPD)Premature BirthsCritical Illness
Duke UniversityNCT07101640
Phase 1
A Phase 0/Phase 1 Trial of Metformin for Premature Infants With Bronchopulmonary Dysplasia
The overall objective of this study is to investigate the role of metformin in decreasing lung injury and promoting lung growth in premature infants. There are…
Bronchopulmonary Dysplasia (BPD)
Medical College of WisconsinNCT07120971
Phase 2
Efficacy and Safety of Postnatal Betamethasone for Respiratory Weaning in Extremely Low Gestational Age Neonates (ELGANs) in a Prospective Cohort - Proof of Concept Pilot Study
The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born befor…
Respiratory Distress Syndrome (RDS)Bronchopulmonary Dysplasia (BPD)
Khang NguyenNCT07447739