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10 recruiting studies matching your filters

A Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution in Children and Young Adults With Hematologic Malignancies

The use of venetoclax-based therapies for pediatric patients with relapsed or refractory malignancies is increasingly common outside of the clinical trial sett…

Hematologic MalignancyLeukemiaLymphoma+16 more

Estimated

~$10 – $675

Children's Hospital Medical Center, CincinnatiNCT06131801

Phase 3

A Global, Multicenter, Open Label, Randomized, Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients With Chronic Phase Chronic Myeloid Leukemia (CML-CP)

Study comparing efficacy and safety of olverembatinib (investigational arm) vs. bosutinib (control arm) in patients with CML-CP (Part A). Study will also evalu…

Chronic Myeloid LeukemiaCMLCML, Chronic Phase

Estimated

~$10 – $8,750

Ascentage Pharma Group Inc.NCT06423911

Phase 2

Optimized Cord Blood Transplantation for the Treatment of High-Risk Hematologic Malignancies in Adults

Cord blood transplants (CBT) are a standard treatment for adults with blood cancers. MSK has developed a standard ("optimized") practice for cord blood transpl…

Acute Myelogenous Leukemia (AML)Acute Lymphoblastic Leukemia (ALL)Chronic Myelogenous Leukemia (CML)+3 more

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT05884333

Phase 1

Risk Stratified Treatment for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia: A Phase I/II Non-randomized Study of Trametinib and Azacitidine With or Without Chemotherapy (IND #164058)

This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly d…

Leukemia, Juvenile MyelomonocyticJMMLJCML+2 more

Estimated

~$10 – $7,500

Therapeutic Advances in Childhood Leukemia ConsortiumNCT05849662

Phase 1

TACTICAL: TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT

The purpose of this study is to test the feasibility and safety of early cessation of tacrolimus following allogeneic hematopoietic cell transplantation (HCT).…

GVHDHematopoietic Cell Transplantation (HCT)Acute Myeloid Leukemia (AML)+4 more

Estimated

~$10 – $6,250

Stanford UniversityNCT07302776

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic maligna…

Hematologic MalignanciesInherited Disorders of MetabolismInherited Abnormalities of Platelets+14 more

Estimated

~$10 – $1,125

Center for International Blood and Marrow Transplant ResearchNCT01351545

Phase 2

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who hav…

AML (Acute Myelogenous Leukemia)Acute Lymphoid Leukemia (ALL)Acute Leukemia (Category)+8 more

Estimated

~$10 – $7,500

Center for International Blood and Marrow Transplant ResearchNCT06859424

Phase 1

Feasibility Study of CD34 Selection for GVHD Prophylaxis Using the Automated CliniMACS

Patients with graft failure or delayed engraftment may benefit from a hematopoietic stem cell boost or an additional hematopoietic stem cell transplantation pr…

AMLALLLymphoid Malignancies+3 more

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT06047886

Phase 1

A Phase 1 Study of ABL001 in Combination With Dasatinib, Prednisone, and Blinatumomab in Patients With BCR-ABL Positive (BCR-ABL+) B-cell Acute Lymphoblastic Leukemia (B-ALL) and Chronic Myeloid Leukemia (CML)

This research study is evaluating a drug called ABL001 taken in combination with dasatinib (Sprycel®) and prednisone (a steroid) as a possible treatment for B-…

B-cell Acute Lymphoblastic LeukemiaChronic Myeloid Leukemia (CML) in Lymphoid Blast CrisisPhiladelphia Chromosome Positive Acute Lymphoblastic Leukemia Ph+ ALL

Estimated

~$10 – $7,500

Marlise Luskin, MDNCT03595917

Phase 1

A Phase 1a/1b Study of ELVN-001 for the Treatment of Chronic Myeloid Leukemia

The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients wi…

Chronic Myeloid LeukemiaChronic Phase Chronic Myeloid Leukemia, BCR-ABL1 PositiveCml

Estimated

~$10 – $8,750

Enliven TherapeuticsNCT05304377