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A Molecularly Driven Phase 1b Dose Escalation and Dose Expansion Study of the DNA-PK Inhibitor Peposertib (M3814) in Combination With the ATR Inhibitor Tuvusertib (M1774)

This phase I trial tests the safety, side effects and best dose of peposertib (M3814) in combination with tuvusertib (M1774) in treating patients with solid tu…

Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05687136

Phase 4

Investigator-led Observational Clinical Research Project Evaluating the Impact of the ReFeel for Digital Nerve Injuries.

This is an Investigator Led single-center, Prospective and Observational, Clinical Research Project. The specific aim of this study is to test/observe the safe…

Digital Nerve InjuryNerve Reconstruction

Estimated

~$10 – $8,750

OrthoCarolina Research Institute, Inc.NCT07524465

Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures

The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.

Fracture; PelvicInsufficiency FracturesFragility Fracture+3 more

Estimated

~$10 – $1,050

SI-BONE, Inc.NCT07530497

Phase 1

A Phase 1a/1b Trial of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

The main purpose of this study is to assess safety \& tolerability and antitumor activity of LY3962673 as monotherapy and in combination with other chemotherap…

Pancreatic Ductal AdenocarcinomaNon-small Cell Lung CancerColorectal Cancer

Estimated

~$10 – $7,500

Eli Lilly and CompanyNCT06586515

Phase 1

BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder

This study is open to women who have early-stage breast cancer and are on aromatase inhibitor (AI) therapy, and who have hypoactive sexual desire disorder (HSD…

Early-stage Breast CancerHypoactive Sexual Desire DisorderHormone Receptor Positive Breast Carcinoma+1 more

Estimated

~$10 – $6,250

University of Illinois at ChicagoNCT07596212

Observational

The Effect of Low Volume Sprint Interval Training on Cardiorespiratory Fitness--a Randomized Controlled Trial

Low levels of physical activity (PA) are related to poor health and greater risk of premature death in adults. Lack of time is cited as a primary barrier to pa…

Inactivity, PhysicalOverweight (BMI > 25)Healthy Participants

Estimated

~$10 – $6,250

California State University, San MarcosNCT07328568

Phase 2

An Open-Label, Single-Arm, Phase 2 Study to Evaluate the Efficacy and Safety of Tislelizumab Plus Chemotherapy in a First-Line Setting for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in US Racial and Ethnic Minority Patients

The purpose of this study is to characterize the clinical effects of tislelizumab, including pharmacokinetics (PK), activity, and safety assessments in US raci…

Advanced Unresectable Gastric AdenocarcinomaEsophageal Squamous Cell CarcinomaAdvanced Gastroesophageal Adenocarcinoma

Estimated

~$10 – $7,500

BeOne MedicinesNCT07554521

Observational

Community-Based Preventative Cardiometabolic Screening and Health Coaching- A Prospective Study

The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food…

Cardiovascular Disease PreventionCardiometabolic DiseasesCardiovascular Risk Factor+6 more

Estimated

~$10 – $6,250

Rush University Medical CenterNCT06907524

Phase 1

A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Background: A new cancer therapy involves taking white blood cells from a person, growing them in the lab, genetically modifying them, then giving them back t…

Pancreatic CancerGastric CancerGastrointestinal Cancer+2 more

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT03190941

Studies of Disorders With Increased Susceptibility to Fungal Infections

Background: \- Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the …

Fungal InfectionsPrimary Immune Deficiencies

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT01222741

Observational

PREACTIVE: Preconditioning With REsistance and AerobiC Training to ImproVe Exercise Intolerance and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsenin…

Atrial Fibrillation (AF)Atrial Fibrillation (Paroxysmal)Persistent Atrial Fibrillation+1 more

Estimated

~$10 – $6,250

Northwestern UniversityNCT07324772

Phase 3

A Multicenter, Randomized, Controlled, Open-label, Phase III Study to Assess Efficacy and Safety of Libevitug Injection in Participants With Chronic Hepatitis Delta Virus Infection (D-clear Study)

This is an international, multicenter, randomized, controlled, open-label Phase III trial. It will evaluate the efficacy and safety of libevitug in participant…

Chronic Hepatitis D Infection

Estimated

~$10 – $7,500

Huahui HealthNCT07499544