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Evaluating the Use of Antibiotic-Coated Braided Sutures in Debridement, Antibiotic, and Implant Retention (DAIR) Procedures

The purpose of this study is to evaluate whether the use of antibiotic-coated (triclosan) braided sutures is non-inferior or potentially superior to standard m…

Prosthetic Joint InfectionDebridement With Prosthesis RetentionProsthetic Joint Infections of Hip+2 more

Estimated

~$10 – $6,250

University of MiamiNCT07322289

Phase 2

A Phase 2 Study of Odronextamab in Relapsed/ Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL) Before and After Chimeric Antigen Receptor (CAR) T-Cell Therapy

This phase II trial tests how well odronextamab works before and after standard of care (SOC) chimeric antigen receptor (CAR) T-cell therapy in treating patien…

Recurrent Diffuse Large B-Cell LymphomaRecurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell Lymphoma+1 more

Estimated

~$10 – $6,250

University of California, DavisNCT06854159

Phase 2

A Phase 2 Clinical Study to Evaluate the Pharmacokinetics, Safety, and Efficacy of Doravirine and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in Participants With HIV-1, Who Are 4 Weeks to Less Than 12 Years of Age and Weigh Less Than 45 kg

This is a single-group, open-label, multi-site study in pediatric participants with human immunodeficiency virus type 1 (HIV-1) infection, aged 4 weeks to \<12…

Human Immunodeficiency Virus (HIV) Infection

Estimated

~$10 – $8,750

Merck Sharp & Dohme LLCNCT04375800

Phase 1

A Phase 1/2 Open-label Intrathecal Administration of MELPIDA to Determine Its Safety and Efficacy for Patients With Spastic Paraplegia Type 50 (SPG50) Caused by Mutation in the AP4M1 Gene.

MELPIDA is proposed for the treatment of subjects with SPG50 and targets neuronal cells to deliver a fully functional human AP4M1 cDNA copy via intrathecal inj…

Spasticity, MuscleMicrocephalyIntellectual Deficiency+3 more

Estimated

~$10 – $8,750

Elpida Therapeutics SPCNCT05518188

Phase 1

Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan (Treat HF)

To determine feasibility of recruitment and tolerability of treatment with sacubitril-valsartan among adult age survivors of cancer diagnosed at or before age …

Heart FailureHeart Dysfunction

Estimated

~$10 – $6,250

Virginia Commonwealth UniversityNCT05194111

Phase 2

A Phase II Study of Combination Epcoritamab-Lenalidomide in Patients With Refractory/Relapsed Immunodeficiency-Related Large B-Cell Lymphoma

This phase II trial tests how well the combination of epcoritamab and lenalidomide work in treating patients with immunodeficiency-related large B-cell lymphom…

Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Polymorphic Post-Transplant Lymphoproliferative DisorderRefractory B-Cell Non-Hodgkin Lymphoma

Estimated

~$10 – $7,500

Reem KarmaliNCT06723457

Observational

Pivotal, Prospective, Randomized, Controlled, Multicenter Clinical Trial of BioPoly® Partial Resurfacing Knee Implant for Treatment of Focal Cartilage Lesions of the Distal Femur

The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the t…

Knee Pain ChronicKnee OsteoarthritisCartilage Damage+3 more

Estimated

~$10 – $8,750

BioPoly LLCNCT06915363

Phase 1

Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Reconstruction

The purpose of the study is to determine whether pharmacologic delay using minoxidil in patients undergoing bilateral risk reducing mastectomy with reconstruct…

Breast ReconstructionPerfusion; ComplicationsHigh Risk for Breast Cancer+1 more

Estimated

~$10 – $6,250

Duke UniversityNCT07264790

Observational

Implement and Evaluate the CARE Tool in a Randomized Trial

This study is a multi-site randomized trial to study the implementation of the CARE Tool and evaluate the CARE Tool. The CARE Tool is a web-based tool that giv…

Gynecologic CancerProstate CancerLung Cancer+1 more

Estimated

~$10 – $6,250

Washington University School of MedicineNCT07296887

Observational

Primary Subtalar Arthrodesis for Calcaneal Fractures to Optimize Performance: A Randomized Clinical Trial

Management of severe injuries to the heel (displaced intra-articular calcaneus fractures) continues to be a major challenge for orthopedic surgeons. Previous s…

Calcaneus Fracture

Estimated

~$10 – $6,250

Wake Forest University Health SciencesNCT06249126

Eating Disorders Genetics Initiative 2

The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The inves…

Anorexia NervosaBulimia NervosaBinge-Eating Disorder+1 more

Estimated

~$10 – $750

University of North Carolina, Chapel HillNCT06594913

A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer

Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies. Current diag…

Hepatocellular Carcinoma (HCC)CholangiocarcinomaPancreatic Ductal Adenocarcinoma (PDAC)+3 more

Estimated

~$10 – $750

City of Hope Medical CenterNCT07224750