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A Phase 1/2, Open-label Study of VS-7375, a KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and in Combination, in Patients With Advanced KRAS G12D-Mutated Solid Tumors
This study will assess the safety and efficacy of VS-7375 alone and in combination in patients with advanced solid tumors harboring a KRAS G12D-mutation.
HeartGPS: A Longitudinal Randomized Controlled Trial Examining the Effects of a Prenatally-Delivered Psychological Intervention for Parents and Their Babies With Single Ventricle Congenital Heart Disease
Babies with single ventricle congenital heart disease (SVCHD) are often diagnosed during pregnancy. While prenatal diagnosis has important clinical benefits, i…
Examining Influence of Social Media Ads on Black and White Adolescents' Food Choices: Master ClinicalTrials.Gov Protocol for Aim 1 (NCT05380505), Aim 2 (NCT06969638) and Aim 3 (NCT06969651).
This is a Master ClinicalTrials.gov Protocol for study 20-01796: Aim 1: Examining Influence of Social Media Ads on Black and White Adolescents' Food Choices -…
A Single-Arm Phase II Clinical Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel as Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma
This phase II trial tests how well gemcitabine, cisplatin and nab-paclitaxel given before surgery (neoadjuvant) works in treating patients with pancreatic canc…
First in Human Phase 1 Study of AOH1996 in Patients With Refractory Solid Tumors
This phase I trial studies the side effects and best dose of AOH1996 in treating patients with solid tumors that do not respond to treatment (refractory). AOH1…
Personalized Engine for Speed of Information Processing
(JUSTIFICATION: This is the R33 stage of an NIH funded R21/R33 study. R21 stage (IRB-61727) was focused on intervention development; R33 stage will focus on pi…
Double-S: a Wearable Device for Erectile Dysfunction
The purpose of this study is to use a minimally invasive erectile device for patients suffering from erectile dysfunction.
B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair
A prospective, single-center, non-blind, non-randomized safety and feasibility study of the hybrid repair of thoracic aortic pathologies requiring repair of th…
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest dra…
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aim…
Liver Transplantation for Unresectable Liver Limited Colorectal Metastases
This is a single-arm, single institution pilot registry of liver transplantation in patients with unresectable colorectal liver-only metastases at Weill Cornel…
A Pilot, Single-Arm, Phase II Trial of Tamoxifen Plus Pegylated Liposomal Doxorubicin in Patients With Metastatic Triple Negative Breast Cancer
This phase II trial tests how well tamoxifen and pegylated liposomal doxorubicin works in treating patients with triple negative breast cancer that has spread …