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3,843 recruiting studies matching your filters

Phase 1/2a Open-Label, Dose-Escalation, Multicenter, FIH, Consecutive-Cohort, Clinical Trial of BI-1808, a Monoclonal Antibody to TNFR 2 as a Single Agent and in Combination With Pembrolizumab (MK-3475-D20) in Subjects With Advanced Malignancies

The goal of this first in human clinical trial is to test BI-1808 administered as single agent and in combination with pembrolizumab in subjects with advanced …

Advanced MalignanciesOvarian CancerT-cell Lymphoma+1 more

Estimated

~$10 – $7,500

BioInvent International ABNCT04752826

Phase 1

A Single and Repeat Dosing and Expansion Study of the Safety, Drug Exposure and Clinical Activity of R-5780 in Combination With a PD-1 (Checkpoint Protein on Immune Cells Called T Cells) Pathway Checkpoint Inhibitor in Patients With Solid Tumors

The goal of this study is determine the safety and tolerability of orally taken probiotic (R-5780) in patients currently on a PD-1 Pathway Checkpoint Inhibitor…

Solid Tumor, AdultSolid TumorMelanoma+3 more

Estimated

~$10 – $8,750

Rise Therapeutics LLCNCT06398418

Using Infrared Spectroscopy to Analyze Volatile Organic Compounds in the Breath of Patients to Detect Breast Cancer

Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be…

Breast Cancer

Estimated

~$10 – $1,050

Breathe BioMedical IncNCT06512350

Phase 1

GLP-1 Receptor Agonist Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

There is a growing number of patients diagnosed with gastrointestinal cancers who are also simultaneously being treated with GLP-1 Receptor Agonists (RA)s. To …

Pancreatic CancerColorectal CancerHepatocellular Carcinoma

Estimated

~$10 – $6,250

University of ArizonaNCT07627191

Observational

Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment

This project will evaluate the feasibility and acceptability of Empowered Relief (ER) among American Indian adults who are currently receiving or have complete…

CancerPainPain Management+2 more

Estimated

~$10 – $6,250

University of OklahomaNCT07742449

Phase 3

A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression

Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.

Non-Small Cell Lung Cancer

Estimated

~$10 – $8,750

Summit TherapeuticsNCT06767514

Phase 2

A Phase II Study on Photodynamic Diagnosis of Urological Cancer in the Kidney Using Fluorescence Endoscopy With Cystoscopy and Ureteroscopy With 5-ALA

The goal of this prospective, single-arm feasibility study is to evaluate the safety and feasibility of using Gleolan® (5-aminolevulinic acid), an FDA-approved…

Kidney Cancers

Estimated

~$10 – $6,250

Henry Ford Health SystemNCT07828704

A Pilot Study Assessing the Safety of an Active Surveillance Approach to Local Therapy in Patients With Brain Metastases Undergoing CNS-Penetrating Systemic Therapy

This is a Pilot clinical trial determining the safety of an active surveillance approach to local therapy in subjects with brain metastases. These are subjects…

Brain CancerBrain Cancer MetastaticNervous System Cancer+1 more

Estimated

~$10 – $750

University of California, IrvineNCT07827001

Phase 2

TBCRC Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies (EVOLVE-BDT)

This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/horm…

Breast CancerMetastatic Breast CancerTriple Negative Breast Cancer+2 more

Estimated

~$10 – $6,250

UNC Lineberger Comprehensive Cancer CenterNCT07340541

Phase 1

Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)

To find the best dose of ADI-PEG20 that can be given in combination with carboplatin and cabazitaxel to patients with AVPC.

Prostate Cancer

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT06085729

Observational

Feasibility Pilot of the Adapted Adolescent and Young Adult Patient Advocacy, Real-Time Navigation, Equity and Reach (AYA-PARTNER) Intervention To Address Unmet Needs of AYAs Undergoing Active Cancer Treatment

This is a single-center, non-randomized feasibility pilot study of an adapted Adolescent and Young Adult Patient Advocacy, Real-Time Navigation, Equity and Rea…

CancerMalignancies Multiple

Estimated

~$10 – $6,250

UNC Lineberger Comprehensive Cancer CenterNCT07829146

Phase 2

A Phase II Study Evaluating T-Cell Clonality After Stereotactic Body Radiation Therapy Alone and in Combination With the Immunocytokine PDS01ADC in Localized High and Intermediate Risk Prostate Cancer Treated With Androgen Deprivation Therapy

Background: Prostate cancer is often treated with radiation and ADT (ADT is androgen deprivation therapy). Up to 30% of these cancers recur within 5 years of …

Cancer Of Prostate

Estimated

~$10 – $5,625

National Cancer Institute (NCI)NCT05361798