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9 recruiting studies matching your filters

A Phase 2 Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis

Background: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as Autoimmune polyendocrine syndrome type-1 (APS-1), is a dise…

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Enteritis

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT07202598

Phase 3

An Interventional Efficacy and Safety Phase 3 Double-blind 2-arm Study to Investigate IV Followed by Oral Fosmanogepix Compared With IV Caspofungin Followed by Oral Fluconazole in Adult Participants With Candidemia and/or Invasive Candidiasis

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Fosmanogepix) for the potential treatment of candidem…

CandidemiaCandidiasis, Invasive

Estimated

~$10 – $8,750

Basilea PharmaceuticaNCT05421858

Remote eligible

The Natural History and Pathogenesis of Human Fungal Infections

Background: \- The immune system is made up of special cells, tissues, and organs that fight infections. Problems with this system may lead to frequent, sever…

Chronic Mucocutaneous CandidiasisInvasive AspergillosisCARD9+1 more

Estimated

~$10 – $675

National Institute of Allergy and Infectious Diseases (NIAID)NCT01386437

A Non-Significant Risk Specimen Collection Study to Obtain Vaginal Swab Samples for Algorithm Development and Testing

In this pilot study, prospectively acquired clinician-collected and participant-collected vaginal swab specimens will be obtained from up to 1000 individuals w…

Bacterial InfectionsBacterial Infections and MycosesInfections+10 more

Estimated

~$10 – $1,050

Nanopath, IncNCT07607470

Phase 2

A Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata

Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune syste…

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (Apeced)Alopecia Areata

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT05398809

Phase 2

A Randomized, Double-Blind, Placebo-Controlled Phase 2a Study Evaluating the Safety, Tolerability, and Efficacy of OCF001 Intravaginal Gel in Women With Acute Vulvovaginal Candidiasis

A Randomized, Double-Blind, Placebo-Controlled Phase 2a Study Evaluating the Safety, Tolerability, and Efficacy of OCF001 Intravaginal Gel in Women with Acute …

Candidiasis, Vulvovaginal

Estimated

~$10 – $8,750

Sano Chemicals IncNCT07521137

Observational

Open-label, Uncontrolled Clinical Research Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)

The objective of this study is to determine clinical cure rate and safety of a proprietary Vaginal Cooling Device (VCD) in women with VCC. In addition, the saf…

Vulvovaginal Candidiasis (VVC)Yeast Vaginitis

Estimated

~$10 – $8,750

Coologics, IncNCT06983041

Observational

Short Course Versus Standard Course Antifungal Therapy for Uncomplicated Candidemia in Children and Adolescents: A Multi-Center Randomized Controlled Trial

The goal of this clinical trial is to compare antifungal therapy duration in pediatric uncomplicated candidemia. The specific aims are: * Compare the desirabi…

Invasive Candidiasis

Estimated

~$10 – $6,250

Arkansas Children's Hospital Research InstituteNCT05763251

Phase 1

Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome

This project aims to investigate if the contraceptive method, Phexxi, causes changes to the composition of the vaginal microbiome. The investigators hypothesiz…

Bacterial VaginosisVulvovaginal Candidiasis

Estimated

~$10 – $6,250

Queen's Medical CenterNCT05753813