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Phase 1

A Phase 1/2, First-in-human, Multicenter Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

A Study of Emi-Le in Participants with Solid Tumors

Triple Negative Breast CancerBreast CancerEndometrial Cancer+4 more

Estimated

~$10 – $8,750

Day One Biopharmaceuticals, Inc.NCT05377996

Phase 2

Phase II Clinical Trial of FOLFOX, Botensilimab, Plus Balstilimab in Patients With Localized Rectal Cancer

This phase II trial tests how well fluorouracil, oxaliplatin and leucovorin calcium (folinic acid) (FOLFOX) with botensilimab and balstilimab given before surg…

Rectal AdenocarcinomaStage IIA Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8

Estimated

~$10 – $6,250

City of Hope Medical CenterNCT06780787

Molecular Profiling for Tumor Characterization and Risk Stratification in Patients With Appendiceal Cancer

This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient …

Appendiceal CancerAppendiceal Adenocarcinoma

Estimated

~$10 – $750

City of Hope Medical CenterNCT07587268

Phase 1

A First-in-human Phase 1 Dose-escalation Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of KST-6051 in Patients With Advanced or Metastatic Solid Tumors With a KRAS Mutation

The main purpose of the trial is to assess whether the trial drug, KST-6051, is safe and tolerable when administered orally to adults with advanced or metastat…

KRAS-mutant Non-small Cell Lung Cancer (NSCLC)KRAS-mutant Pancreatic Ductal Adenocarcinoma (PDAC)KRAS-mutant Colorectal Cancer (CRC)+1 more

Estimated

~$10 – $8,750

Kestrel Therapeutics, Inc.NCT07458347

Phase 1

Stop LCNP: High Dose Steroid Therapy for Late Radiation-Associated Lower Cranial Neuropathy: A Phase I/II Dose Finding Trial and Data Registry

This phase I/II trial studies the side effect and best dose of steroid therapy (prednisone or methylprednisolone) in improving symptoms of late radiation-assoc…

Cranial Nerve DisorderHead and Neck CarcinomaOropharyngeal Carcinoma

Estimated

~$10 – $6,250

M.D. Anderson Cancer CenterNCT04151082

Phase 2

A Phase 2 Open Label Study of XL092 as First Line Therapy in Radioiodine Refractory Differentiated Thyroid Cancer

This phase II trial tests how well XL092 works for the treatment of patients with differentiated thyroid cancer that has not responded to previous treatment wi…

Locally Advanced Differentiated Thyroid Gland CarcinomaLocally Advanced Poorly Differentiated Thyroid Gland CarcinomaLocally Advanced Thyroid Gland Follicular Carcinoma+18 more

Estimated

Phase 1

Phase I Study of Gilteritinib for ALK Positive Non-Small Cell Lung Cancer

This phase I trial is studying the safety, side effects, and best dose of gilteritinib in treating patients with stage IV ALK positive non-small cell lung canc…

Lung Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8

Estimated

~$10 – $6,250

University of Michigan Rogel Cancer CenterNCT06225427

Observational

Prospective Phase 2 Trial of Yttrium-90 Radiation Segmentectomy for Unresectable Hepatocellular Carcinoma

This is a prospective, single-blinded, single-arm, open-label Phase II trial of trans-arterial radiation segmentectomy using Yttrium-90 glass microspheres (The…

Hepatocellular CarcinomaUnresectable Hepatocellular CarcinomaHepatocellular Cancer+1 more

Estimated

~$10 – $5,625

University of California, San FranciscoNCT07110233

Phase 1

Comparative Evaluation of Nicotine Analogs

This phase I trial compares electronic cigarette (EC) user preferences and smoking behaviors of nicotine analogs to nicotine to improve the understanding of ni…

Tobacco-Related CarcinomaAddiction

Estimated

~$10 – $6,250

Ohio State University Comprehensive Cancer CenterNCT07585006

Addition of F18-Piflufolastat PET/CT to Cross-Sectional Imaging for the Staging and Management of Hepatocellular Carcinoma

This prospective, single-center study evaluates the clinical utility of F18-Piflufolastat (PSMA) PET/CT when added to conventional cross-sectional imaging for …

Hepatocellular Carcinoma (HCC)

Estimated

~$10 – $675

VA Office of Research and DevelopmentNCT07019844

Phase 2

A Phase II Study Evaluating Neoadjuvant Ivonescimab for Resectable Head and Neck Cancer

This phase II trial tests how well ivonescimab before surgery works in treating patients with stage II-IV head and neck cancer that can be removed by surgery (…

Advanced Head and Neck Squamous Cell CarcinomaResectable Head and Neck Squamous Cell CarcinomaStage II Head and Neck Cutaneous Squamous Cell Carcinoma+2 more

Estimated

~$10 – $6,250

University of Michigan Rogel Cancer CenterNCT07094685

Phase 1

A Phase Ib/II Study of Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Hepatocellular Carcinoma

This phase Ib/II trial tests the safety, side effects, and best dose of zanzalintinib and how well it works in treating patients with hepatocellular (liver) ca…

Advanced Hepatocellular CarcinomaCirrhosisStage III Hepatocellular Carcinoma AJCC v8+1 more

Estimated

~$10 – $7,500

Devalingam MahalingamNCT07042919