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78 recruiting studies matching your filters

Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete or Partial Responders

This randomized phase II trial studies how well obinutuzumab works as maintenance treatment in patients with central nervous system lymphoma who have achieved …

Primary Central Nervous System Lymphoma

Estimated

~$75 – $3,000

Actual pay is set by the research site.

Providence Health & ServicesNCT06175000

Observational

Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation

The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to di…

StrokeBrain DiseaseCentral Nervous System Diseases+2 more

Estimated

~$10 – $675

Actual pay is set by the research site.

VA Office of Research and DevelopmentNCT04286516

Phase 2

A Prospective, Multicenter Phase 2/3 Study to Assess the Efficacy and Safety of Mangaciclanol in Adult Patients With Known or Highly Suspected Lesions Referred for Contrast-Enhanced Magnetic Resonance Imaging (MRI) of Central Nervous System (CNS) or Body (LUMINA)

This is an operationally combined Phase 2/3 study, which will be conducted and evaluated in 2 distinct parts: * Phase 2: Prospective, adaptive, multicenter, n…

Known or Highly Suspected Central Nervous System (CNS) LesionKnown or Highly Suspected Body (Excluding CNS) Lesion

Estimated

~$75 – $3,000

Actual pay is set by the research site.

GE HealthcareNCT07472491

Observational

Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous syst…

Central Nervous System Cancer

Estimated

~$10 – $750

Actual pay is set by the research site.

Abramson Cancer Center at Penn MedicineNCT07147179

Phase 2

Phase 2 Study of Avapritinib in Patients With CKIT or PDGFRA Mutation-Positive Malignant Solid Tumors

This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have sprea…

Anatomic Stage IV Breast Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8+26 more

Computer-based Neurocognitive Assessment in Children With Central Nervous System Tumors Receiving Proton Beam Radiation Therapy

This study will explore neurocognitive performance in pediatric brain tumor patients receiving proton beam radiation therapy (PBRT). The investigators goal is …

Central Nervous System

Estimated

~$10 – $750

Actual pay is set by the research site.

Washington University School of MedicineNCT02559752

Observational

GEMINI - Cancer Genetic Testing in Ethnic Populations

This clinical trial examines the integration of cancer genetic testing in various ethnic populations. Studying individuals and families at risk of cancer may h…

Breast CarcinomaCarcinoma of Unknown PrimaryCentral Nervous System Carcinoma+8 more

Estimated

~$10 – $750

Actual pay is set by the research site.

Mayo ClinicNCT04475640

A Feasibility Study to Determine if a Novel Patient-derived Explant Platform Can Produce Drug Sensitivity Scores Within a Clinically Relevant Time Frame in Patients With CNS Tumors

This biospecimen collection study will evaluate the feasibility of engrafting and testing resected Central nervous system (CNS) tumors tumor tissue ex vivo to …

Central Nervous System Tumor

Estimated

~$10 – $750

Actual pay is set by the research site.

UNC Lineberger Comprehensive Cancer CenterNCT05978557

Phase 3

A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (IND#:133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-LLy

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-…

B Acute Lymphoblastic LeukemiaB Lymphoblastic LymphomaCentral Nervous System Leukemia+2 more

Estimated

~$50 – $2,250

Actual pay is set by the research site.

Children's Oncology GroupNCT03959085

Phase 1

Phase 1/Phase 2 Open Label Trial of a Novel Indenoisoquinolone C-MYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

Background: Glioblastoma is a common brain cancer in adults. Treatment includes surgery, radiation, and chemotherapy. But this cancer can return after treatme…

Recurrent GlioblastomaGlioblastoma IDH (Isocitrate Dehydrogenase) WildtypeRelapsed Cancer+12 more

Estimated

~$150 – $2,700

Actual pay is set by the research site.

National Institute of Neurological Disorders and Stroke (NINDS)

Phase 1

An Open-label Multicenter Phase 1b-2 Study of Elacestrant in Combination With Abemaciclib in Women and Men With Brain Metastasis From Estrogen Receptor Positive, HER-2 Negative Breast Cancer

This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain m…

Breast NeoplasmsBrain NeoplasmsNeoplasms by Site+5 more

Estimated

~$150 – $4,200

Actual pay is set by the research site.

Stemline Therapeutics, Inc.NCT05386108

Comprehensive Multimodal Analysis of Patients With Neuroimmunological Diseases of the CNS

Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system. …

Central Nervous System DiseaseMultiple Sclerosis

Estimated

~$10 – $675

Actual pay is set by the research site.

National Institute of Allergy and Infectious Diseases (NIAID)NCT00794352