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Phase 2
Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau in Older Adults (IPAT Study)
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Al…
Cognitively Normal Older AdultsHypertensionSubjective Cognitive Decline+1 more
Rong ZhangNCT05331144
Observational
Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan
This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to ass…
NeurotypicalCognitively Normal
University of MinnesotaNCT06127667
Phase 3
Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Disease Using the PET Ligand [18F]-PI-2620
The investigators will compare \[18F\]-PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentati…
Frontotemporal Lobar DegenerationAlzheimer DiseaseCognitively Normal
University of PennsylvaniaNCT05456503