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332 recruiting studies matching your filters

A Phase 1a/1b Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-53038, a Pan-KRAS Inhibitor, as Monotherapy or in Combinations in Patients With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplifications

This is a first-in-human (FIH), open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), …

Metastatic Solid TumorsAdvanced Non-squamous Non-small-cell Lung CancerAdvanced Colorectal Cancer+4 more

A Phase 1/2, Dose Escalation and Expansion Trial to Evaluate the Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma

This trial will evaluate the safety, tolerability, and preliminary efficacy of tegavivint as monotherapy (single) and in combination with standard therapies in…

Metastatic Colorectal Carcinoma (mCRC)Colorectal Cancer (CRC)Adenomatous Polyposis Coli (APC) Gene Mutation+1 more

Estimated

~$10 – $7,500

HonorHealth Research InstituteNCT07463599

Phase 1

A Phase 1/1b, Open-label, Multicenter, Dose Escalation and Dose Optimization Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of KQB365 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies With KRAS G12S or G12C Mutations

The goal of this clinical trial is to learn if KQB365 works to treat advanced solid tumor cancer in adults. It will also learn about the safety of KQB365. The …

KRAS G12C MutationKRAS G12S MutationSolid Tumor Malignancies+1 more

Estimated

~$10 – $8,750

Kumquat Biosciences Inc.NCT06720987

The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

The purpose of this research study is to determine whether testing of stool for a panel of markers will enable us to detect polyps and cancer compared to stand…

Adenocarcinoma of the ColonAdenocarcinoma of the RectumStage I Colorectal Cancer+2 more

Estimated

~$10 – $750

Case Comprehensive Cancer CenterNCT04624555

Phase 2

A Phase 2, Open-label, Multicenter Study of IBI363 (PD1-IL2m) in Subjects with Advanced Solid Malignancies

This is a Phase 2, open-label, multicenter study designed to evaluate the efficacy, safety and tolerability of IBI363 (study drug) in subjects with advanced, r…

MelanomaNon-small Cell Lung CancerColorectal Cancer+1 more

Estimated

~$10 – $8,750

Innovent Biologics (Suzhou) Co. Ltd.NCT06281678

Observational

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

This is a prospective, randomized study designed to compare genotype-guided dosing to usual care in patients with pancreas cancer and colorectal cancer who are…

Colorectal CancerPancreatic Cancer

Estimated

~$10 – $7,500

Reema A. PatelNCT05391126

Phase 1

INFINITIVE: ImmuNotherapy For PatIeNts wIth colorecTal LIVer MEtastases

Nelitolimod is a classC toll-like receptor 9 (TLR9) agonist that binds to TLR9 receptors on myeloid-derived suppressor cells(MDSCs) and helps reshape the tumor…

Colorectal Cancer Metastatic

Estimated

~$10 – $7,500

Northwell HealthNCT07172282

Observational

Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

The purpose of this study is to determine the effectiveness of a digital health program called AYA STEPS, which is designed to help adolescent and young adult …

CancerBreast CancerColorectal Cancer+3 more

Estimated

~$10 – $6,250

Duke UniversityNCT06371768

ColoSense Post Approval Study

The post-approval study (PAS) described here will supplement existing data generated in the CRC-PREVENT clinical trial. The primary outcomes of this supplement…

Colorectal Cancer (Diagnosis)

Estimated

~$10 – $1,050

Geneoscopy, Inc.NCT07069556

Phase 1

A Phase I/Ib Trial of ProAgio, an Anti-avb3 Integrin Cytotoxin, in Combination With 5-fluorouracil , Irinotecan and Bevacizumab for Advanced/Metastatic Colorectal Cancer (ProAgio in CRC)

This is an open-label Phase I/Ib dose-escalation, dose-expansion clinical trial of the safety, pharmacokinetics and clinical activity of ProAgio combined with …

Advanced Colorectal CancerMetastatic Colorectal Cancer

Estimated

~$10 – $6,250

University of Alabama at BirminghamNCT06867822

Translational Utility of Tumor-Derived FGF19 in a Novel Blood-Based Endocrine Suppression Approach

Identify and test thresholds, specificity and sensitivity for a potential cancer associated biomarker protein, FGF19, (and associated markers) for detection in…

Colorectal CancerBreast CancerHealthy

Estimated

~$10 – $750

University of Central FloridaNCT06068257

Phase 2

Phase IIa Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

The goal of this clinical trial is to help learn about the safety and feasibility of hepatic artery infusion chemotherapy for those who have colorectal liver m…

Colorectal Cancer MetastaticIntrahepatic Cholangiocarcinoma

Estimated

~$10 – $7,500

Michael J Cavnar, MDNCT07201519