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4 recruiting studies matching your filters
Phase 1
Phase I/II Trial of Repeat Dosing of Super-Selective Intraarterial Infusion of Erbitux (Cetuximab) and Avastin (Bevacizumab) for Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age
This study assesses the safety and efficacy of repeat monthly dosing of super-selective intra-arterial cerebral infusion (SIACI) of cetuximab and bevacizumab i…
Glioblastoma MultiformeAnaplastic AstrocytomaFibrillary Astrocytomas+5 more
University of MiamiNCT05956821
Phase 1
A Dose Escalation Study Using Eflornithine (DFMO) and AMXT 1501 Followed by a Randomized Controlled Trial of DFMO With or Without AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
The purpose of this study is to evaluate the investigational oral drug AMXT 1501 in combination with oral eflornithine (DFMO). An investigational drug is one t…
Atypical Teratoid/Rhabdoid TumorEmbryonal Tumor With Multilayered RosettesEwing Sarcoma+4 more
Milton S. Hershey Medical CenterNCT06465199
Phase 2
A Phase II Trial of ACT001 in Children and Adolescents With Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
This is a Phase II open-label study to investigate the safety and efficacy of ACT001 in patients with DIPG and H3K27-altered HGG.
Diffuse Intrinsic Pontine Gliomas (DIPG)Progressive DIPGRefractory DIPG+2 more
Nationwide Children's HospitalNCT06838676
A Retrospective and Prospective Observational Sub-Study for Diffuse Midline Glioma and Diffuse Intrinsic Pontine Glioma
This study will gather data from new and existing patients with patient medical records, and patient/family/caregiver reported information to establish a clear…
OncologyDIPGDMG
xCuresNCT06140719