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Weill Medical College of Cornell UniversityNCT06039930

Depression / Major Depressive Disorder

Augmented Depression Therapy (ADepT) Case Series

This research study plans to examine the use of Augmented Depression Therapy (ADepT) in order to evaluate what patients think about ADepT and how well it works…

Ohio State UniversityNCT07733310

Alcohol Use, UnspecifiedRelationship, SocialDepression, Anxiety

User Testing and Feasibility Study of an Intervention Addressing Young Adults' Experiences With Alcohol and Romantic Relationships

Whole Selves is a novel print and online intervention using motivational interviewing principles and personalized feedback to address young adults' alcohol use…

Boston UniversityNCT06392542

Caregiver BurdenStressDepression+2 more

Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular Disease: A Hybrid Effectiveness-Implementation Study of Caregiving Support in Cardiac Rehabilitation

The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilitators to implementation of the Confident…

University of California, DavisNCT07717723

Phase 3

A 6-week, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of the Efficacy and Safety of Cariprazine in Pediatric Subjects (10 to 17 Years of Age) in the Treatment of Depressive Episodes Associated With Bipolar I Disorder

Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The…

DepressionBipolar I Disorder

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

The purpose of this study is to demonstrate whether Behavioral Activation for depression delivered via home based telehealth (BA-HT) is effective in improving …

DepressionCardiovascular Diseases

VA Office of Research and DevelopmentNCT04877197

~$10 – $5,625

Evaluating the Impact of Digital Behavioral Interventions to Address Insomnia and Depression in Breast Cancer Survivors Using an Adaptive Design

Co-occurring symptoms of insomnia and depression is very common in breast cancer survivors, and it is critical that scalable and easily accessible digital beha…

InsomniaDepression

University of VirginiaNCT07721064

Depression - Major Depressive DisorderInsomnia

Feasibility of Using Alpha Phase-Locked Auditory Stimulation for Insomnia Symptoms in People With Depression

The goal of this clinical trial is to determine if alpha phase-locked auditory stimulation can improve sleep in people with insomnia and depression. The main g…

Wake Forest University Health SciencesNCT07553364

Treatment Resistant Depression (TRD)

Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

This study is being conducted at Massachusetts General Hospital (MGH) to explore whether adding psychedelic coaching can enhance the effects of ketamine or esk…

Massachusetts General HospitalNCT07563868

Phase 2

A Randomized, Double-Blind, Placebo-Controlled Mechanistic Study to Assess a Single Oral Dose of CYB003 in Participants With Major Depressive Disorder (MDD) and Moderate to Severe Anxiety

The goal of this study is to learn how psychedelics may help symptoms of depression and anxiety. Participants with major depressive disorder experiencing sympt…

DepressionAnxietyMajor Depressive Disorder

Ohio State UniversityNCT06820723

DepressionAnxietyPost-traumatic Stress Disorder+3 more

Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors: Blueprint 2

Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis…

Duke UniversityNCT06538246

DepressionStressConflict Resolution

Internet Based Psychological Support

The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress…