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2,802 recruiting studies matching your filters

(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000

This study will measure how well PathFinder 1.0 detects retinal abnormalities on macular cube OCT B-scans by assessing its sensitivity and specificity.

Epiretinal MembraneDry Age Related Macular DegenerationMacular Abnormalities+7 more

Estimated

~$10 – $7,500

Carl Zeiss Meditec-Dublin CoCeNCT07680244

Phase 1

An Open-label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered PrP-siRNA in Adult Patients Diagnosed With Symptomatic Prion Disease.

The purpose of this trial is to evaluate safety, tolerability, pharmacokinetics and pharmacodynamic impact of PrP-siRNA in symptomatic prion disease patients.

Prion Disease

Estimated

~$10 – $7,500

Broad Institute of MIT and HarvardNCT07444580

Phase 2

A Phase 2b/3, Double-masked, Randomized, Vehicle-controlled, Multicenter Study Evaluating Licaminlimab in Dry Eye Disease Patients With a Specific TNFR1 Genotype

The primary objective of this study is to evaluate the efficacy and safety of the topical ophthalmic administration of licaminlimab as compared to vehicle in p…

Dry Eye Disease (DED)

A Phase 2b, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

This is a phase 2b, multicenter, randomized, double-blind, placebo-controlled study.

Atopic DermatitisAtopicDermatitis+5 more

Estimated

~$10 – $8,750

Apollo Therapeutics LtdNCT07599813

Observational

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study

This study employs an exploratory, prospective, single center, naturalistic clinical trial design with a randomized crossover intervention.

Parkinson Disease

Estimated

~$10 – $6,250

The Cleveland ClinicNCT07110376

Phase 4

Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics

The main treatment for Parkinson's disease is a medication called levodopa. Levodopa has to be absorbed from the gut and travel to the brain to work, but a nat…

Parkinson's Disease

Estimated

~$10 – $6,250

Beth Israel Deaconess Medical CenterNCT07793461

Phase 2

Open-label, Uncontrolled, Multicenter Trial to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Inebilizumab in Children From 2 Years to Less Than 18 Years of Age With Immunoglobulin G4-related Disease (IgG4-RD)

The primary objectives of this study are to characterize the pharmacokinetics (PK) and pharmacodynamics (PD), as well as to assess the safety and tolerability,…

Immunoglobulin G4-related Disease

Coronary Computed Tomography Angiography (CCTA) for the Pre-procedural Planning of Percutaneous Coronary Intervention: A Randomized Trial of Routine PCI Versus CCTA-guided PCI

The CT-PLAN PCI trial will evaluate whether CCTA-guided PCI improves procedural efficiency compared with routine PCI (without pre-procedural CCTA-guidance for …

Coronary Artery DiseaseCT

Estimated

~$10 – $6,250

Minneapolis Heart Institute FoundationNCT07691502

Dorothy P. and Richard P Simmons Center for Interstitial Lung Disease Research Registry

The purpose of this study is to place past, current, and future medical record information into the UPMC Simmons Center for Interstitial Lung Disease Research …

Lung Diseases, Interstitial

Estimated

~$10 – $750

University of PittsburghNCT00258583

An International Observational Study of Adults With Acute Infection

Prospective, longitudinal studies of people with acute infections are essential to understand risk factors, clinical manifestations, pathobiology, and manageme…

Infectious Disease

Estimated

~$10 – $750

University of MinnesotaNCT07069400

Phase 3

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Telitacicept in Adult Participants With Active Primary Sjögren's Disease

Phase 3 Study of Telitacicept in Active Primary Sjögren's Disease (UPSTREAM SjD)

Primary Sjogren's Disease

Estimated

~$10 – $8,750

Vor BiopharmaNCT07404865

Phase 1

An Open-Label, Proof of Concept Study of Vorinostat for the Treatment of Moderate-to-Severe Crohn's Disease, Ulcerative Colitis, and Chronic Granulomatous Disease Colitis Patients and Maintenance Therapy With Ustekinumab

Background: Crohn s disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut. Symptoms may include diarrhea, abdominal pain, fatigue, …

Crohn's Disease

Estimated

~$10 – $5,625

National Institute of Allergy and Infectious Diseases (NIAID)NCT03167437