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Phase 3
Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslink…
Down Syndrome (DS)KeratoconusPellucid Marginal Degeneration+1 more
Woolfson Eye InstituteNCT07135167
Observational
Pediatric Down Syndrome Post-Approval Study
The purpose of this Post Approval research study is to assess ongoing safety and effectiveness of the Inspire therapy in adolescents and young adults (age 13-1…
Pediatric Obstructive Sleep ApneaDown Syndrome (DS)
Inspire Medical Systems, Inc.NCT06851338
Phase 1
Nicotinamide Adenine Dinucleotide Augmentation to Prevent or Reverse the Progression of Alzheimer's Disease in People With Down Syndrome
The aim of the study is to determine the safety and tolerability of different increasing doses of MIB-626 (a microcrystalline form of β nicotinamide mononucleo…
Down Syndrome (DS)
Brigham and Women's HospitalNCT07278492
Observational
Adapting the RDAD Intervention for Individuals With Down Syndrome Phase 3- Pilot Test
The goal of this clinical trial is to observe feasibility and initial efficacy of a remotely delivered exercise and dementia caregiving intervention in older a…
Down Syndrome (DS)Alzheimer's Disease (AD)
University of Kansas Medical CenterNCT07425769