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CHAMP: Community Health Assessment and Monitoring in the Pharmacy. Assessing the Impact of a Community Pharmacist Lung Cancer Screening (LCS) Program

The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) with low-dose CT for adults aged 50-80 with a ≥20 pack-year smoking histo…

Lung CancerEarly Lung Cancer Detection

Estimated

~$10 – $7,500

Jill KolesarNCT07572773

Prophylactic Lymphovenous Bypass Procedure Following Inguinal Lymphadenectomy or Pelvic Lymphadenectomy: A Prospective Observational Study

To learn if LBP can help to prevent lymphedema when it is performed at the time of surgery rather than after a patient has already developed the disease.

Lymphadenectomy

Estimated

~$10 – $750

M.D. Anderson Cancer CenterNCT05992909

Phase 1

An Open Label, Multicenter Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of IDE574 as Monotherapy in Locally Advanced or Metastatic Solid Tumors and as Combination Therapy With Fulvestrant in Locally Advanced or Metastatic ER+, HER2- Breast Cancer

IDE574 is a synthetically manufactured small molecule inhibitor that co-targets the lysine acetyltransferase enzymes KAT6 and KAT7. The purpose of this study …

ER+, HER 2- Breast CancerNon-small Cell Lung Cancer (NSCLC)Castration-resistant Prostate Cancer (CRPC)+1 more

Estimated

~$10 – $8,750

IDEAYA BiosciencesNCT07540572

Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure

The purpose of this pilot study is to assess the feasibility of longitudinal neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in ut…

Lyme DiseasePost-Treatment Lyme DiseaseChronic Lyme Disease+3 more

Estimated

~$10 – $675

Children's National Research InstituteNCT06026969

Phase 2

A Phase II Study of Neoadjuvant Botensilimab and Balstilimab Immunotherapy for Mismatch Repair Proficient Rectal Adenocarcinoma

The purpose of this study is to find out whether the combination of botensilimab and balstilimab (BOT/BAL) is a safe and effective treatment that causes few or…

Microsatellite Stable Rectal CarcinomaLocally Advanced Rectal Adenocarcinoma

Estimated

~$10 – $6,250

Memorial Sloan Kettering Cancer CenterNCT06843434

Observational

Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar

Purpose: To evaluate the effect of xBar system utilization on clinical outcomes during recovery following colorectal surgery.

Colorectal Cancer

Estimated

~$10 – $8,750

Exero Medical Ltd.NCT07337590

Phase 1

SENTINEL-101: A Phase 1 Dose Escalation and Expansion Study of CLSP-5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors That Harbor the KRas G12V Mutation

Phase 1, open-label, multicenter study to evaluate the safety, tolerability, PK, PD, and preliminary clinical activity of CLSP 5282 when administered to HLA A\…

Advanced Solid TumorNon Small Cell Lung CancerPancreatic Carcinoma+1 more

Estimated

~$10 – $8,750

Clasp Therapeutics, Inc.NCT07650357

Phase 1

Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of Oral MG001

This research study is the first time the new medication MG001 is being tested in people. MG001 is a formulation of mitragynine, a compound that comes from a p…

Safety and Tolerability in Healthy Subjects

Estimated

~$10 – $5,625

National Institute on Drug Abuse (NIDA)NCT07204171

Phase 2

A Phase 2 Study to Evaluate the Efficacy and Safety of Adoptive Transfer of Autologous Tumor Infiltrating Lymphocytes in Patients With Unresectable, Recurrent, or Metastatic Gastrointestinal Stromal Tumors

This phase II trial tests the effect of autologous tumor infiltrating lymphocytes (TILs) in combination with interleukin-2 (aldesleukin) in treating patients w…

Locally Advanced Gastrointestinal Stromal TumorMetastatic Gastrointestinal Stromal TumorRecurrent Gastrointestinal Stromal Tumor+2 more

Estimated

~$10 – $7,500

Joal BeaneNCT07647068

A Prospective, Observational Study to Evaluate C. Difficile Toxin Levels in Stool in Healthy Individuals Following Standard of Care Antibiotic Treatment for CDI.

Hospitals and clinics interested in participating in this multi-site study, please contact the people mentioned under "Contacts and Locations". The goal of th…

Clostridioides Difficile Infection Recurrence

Estimated

~$10 – $1,125

Bactolife A/SNCT07250724

Epidemiological Burden of and Risk Factors for Ganciclovir Resistant/Refractory Cytomegalovirus in Solid Organ Transplant and Hematopoietic Stem Cell Transplant Patients: Multicentre Cohort Study

The ReCySOHT study is a multicenter, retrospective, observational case-control study on the risk factors for developing a ganciclovir-resistant/refractory (GCV…

Cytomegalovirus Infections

Estimated

~$10 – $1,125

IRCCS Azienda Ospedaliero-Universitaria di BolognaNCT05234723

Observational

The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer.

This trial (molecular characterization trial) focuses on rectal cancer, a common cancer that is treated with radiotherapy (RT) as standard of care and represen…

Rectal Cancer

Estimated

~$10 – $6,250

Weill Medical College of Cornell UniversityNCT05943210