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Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times…
A Rigid Body Database on Human Movement
This study will collect information on the different ways people control limb and body movements. This information will be used to develop a database on normal…
Botulinum Toxin for the Treatment of Neurological Disorders
BTX has been used since the 1980s in support of the research mission of NINDS. Initial studies were focused on expanding the applicability of BTX treatment to …
Phenotype/Genotype Correlations in Movement Disorders
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagn…
A Center Based Early Intervention Program For Preschoolers With Developmental Disorders
The purpose of this study is to examine the effectiveness of a 12-week early intervention program that will include 12 weekly hours in an intensive center-base…
Natural History Protocol for Movement Disorders
Background: A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders caus…
Genetic Characterization of Movement Disorders and Dementias
Background: There are two basic types of movement disorders. Some cause excessive movement, some cause slowness or lack of movement. Some of these are caused …
A Randomized, Double-Blind, Parallel-Group, Dose-Controlled Study Evaluating the Safety and Efficacy of RE104 for Injection in the Treatment of Adjustment Disorder in Patients With Cancer and Other Medical Illnesses
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with …
A Neural Basis for Cognitive Decline Following Deep Brain Stimulation
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this stud…
Rural Autistic Individuals - Supporting Expression
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minima…
Identification of Treatment Parameters That Maximize Language Treatment Efficacy For Children
The goal of this clinical trial is to compare word learning outcomes in late talking toddlers who are taught different types of words. The main question it aim…
Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders
The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's diseas…