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The Role of Inflammation in Central Nervous System (CNS) Mechanisms of Anhedonia and Psychomotor Slowing in Depressed People With HIV
The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribut…
Testing an Adaptive Intervention for Peer-Supported Mobile Health for Primary Care Veterans With Psychological Distress
Many Veterans experience psychological distress including depression, PTSD, anxiety and problems with sleep and anger. Services to address these problems need …
The "What Is Important to Us" Communication Intervention Pilot Clinical Trial
The objective of this study is to conduct a pilot randomized controlled trial (RCT) of a photo-narrative communication intervention developed by our study team…
3-D Tractography Focused Ultrasound Ablation for Essential Tremor
The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging…
Establishing Glutamatergic Changes as the Mechanism of Action in the Rapid Antidepressant Effects of Ketamine
In the treatment of Major Depressive Disorder (MDD), ketamine can produce rapid but short-lasting improvements in mood. In order to develop a new generation of…
Mindfulness and Cardiometabolic Health for Spanish Speaking Latina Pregnant Women: A Community-informed Project Targeting Inflammatory Gene Expression and Glycemic Control
A pilot randomized control trial (RCT) to examine the efficacy of a culturally tailored mindfulness intervention upon fasting cardiometabolic factors (includin…
Phase I Study of HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma (HEROS 3.0)
The purpose of this study is to learn whether it is safe to give HER2-CAR T cells in combination with an immune checkpoint inhibitor drug (pembrolizumab or niv…
Blood Pressure Care for Advancing Real-World Evidence (BPCARE): an RCT of Adherence
The goal of this randomized clinical trial is to determine whether a community health worker-delivered, multi-component behavioral intervention can improve ant…
Group Psilocybin-assisted Cognitive Behavioral Therapy for Major Depressive Disorder
This study will seek to determine the (1) acceptability and (2) feasibility of psilocybin as an adjunct to cognitive-behavioral therapy, delivered as a group t…
Intervening to Promote Tobacco Cessation Following Psychiatric Hospitalization
Cigarette smoking is the leading cause of death and disability in the United States. People with psychiatric disorders consume almost half (44.3%) of all cigar…
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression
The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highe…
Care Coordination and Passive Mobile Data Monitoring to Engage Veterans and Improve Mental Health Care
Providing care to individuals with serious mental illness can be challenging, requiring ongoing monitoring, treatment adjustments, and coordination of various …